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. 1991 Mar;11(3):1739–1744. doi: 10.1128/mcb.11.3.1739

Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0.

X He 1, R Gerrero 1, D M Simmons 1, R E Park 1, C J Lin 1, L W Swanson 1, M G Rosenfeld 1
PMCID: PMC369487  PMID: 1705013

Abstract

Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.

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