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. 1991 Mar;11(3):1751–1753. doi: 10.1128/mcb.11.3.1751

Substitution of foreign protein sequences into a chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.

W Debinski 1, C B Siegall 1, D Fitzgerald 1, I Pastan 1
PMCID: PMC369490  PMID: 1671711

Abstract

TGF alpha-PE40 is a chimeric toxin made by replacing domain Ia of Pseudomonas exotoxin (PE) with transforming growth factor alpha (TGF alpha). We have now replaced a portion of domain Ib of PE with different polypeptides or an extra domain III of PE in transforming growth factor alpha-PE40 and maintained cell killing. Thus, TGF alpha-PE40 can be used to transport foreign protein sequences into the cytosol of cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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