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. 1992 Mar;12(3):1234–1238. doi: 10.1128/mcb.12.3.1234

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.

A Lazaris-Karatzas 1, N Sonenberg 1
PMCID: PMC369555  PMID: 1532049

Abstract

We present evidence that eIF-4E, the mRNA 5' cap-binding protein, cooperates with two immortalizing oncogenes, v-myc and E1A, to cause transformation of rat embryo fibroblasts. eIF-4E alone can transform rat embryo fibroblasts when selection is applied. The pattern of transformation by eIF-4E is similar to that of p21 Ras, raising the possibility that eIF-4E shares a common signal transduction pathway with p21 Ras.

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Selected References

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