Abstract
Willoughby, Donald S. (University of Minnesota, Minneapolis), and Dennis W. Watson. Host-parasite relationships among group A streptococci. II. Influence of sex on the susceptibility of inbred mice toward streptococcal infection. J. Bacteriol. 87:1457–1461. 1964—BALB/Sy mice showed marked sex differences in susceptibility to a strain of Streptococcus pyogenes type 18. Castration of the highly susceptible normal adult male increased their resistance 1,000-fold, which approximated that of normal female mice. Treatment of male mice with estrogen and stilbestrol did not affect their resistance significantly. Young, sexually immature male mice, 4 weeks old, were more resistant than mature males. Susceptibility of the resistant females was not affected by age or bilateral ovariectomy, but testosterone injections caused an increase in susceptibility. Treatment of male mice with estrogen and stilbestrol did not modify their resistance. Smears of peritoneal exudates from normal male mice after intraperitoneal injection of streptococci revealed rapid multiplication of the organisms. There was no evidence of multiplication in the resistant normal female and castrated male mice.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- ASBOE-HANSEN G. Hormonal effects on connective tissue. Physiol Rev. 1958 Jul;38(3):446–462. doi: 10.1152/physrev.1958.38.3.446. [DOI] [PubMed] [Google Scholar]
- FOX L. E., CARROLL W. R., GLACY J. Fungistatic actions of estrogens and related compounds. J Am Pharm Assoc Am Pharm Assoc. 1957 May;46(5):276–278. doi: 10.1002/jps.3030460504. [DOI] [PubMed] [Google Scholar]
- LURIE M. B. Mechanisms affecting spread in tuberculosis. Ann N Y Acad Sci. 1950 May 31;52(7):1074–1090. doi: 10.1111/j.1749-6632.1950.tb54008.x. [DOI] [PubMed] [Google Scholar]
- MURPHY W. H., Jr, WATSON D. W. Susceptibility of inbred mice to group A streptococcal infection. Proc Soc Exp Biol Med. 1957 Apr;94(4):755–758. doi: 10.3181/00379727-94-23076. [DOI] [PubMed] [Google Scholar]
- NICOL T., SNELL R. S. Effect of testosterone and androstene 3beta-17alpha-diol on the activity of the reticuloendothelial system. Nature. 1956 Dec 22;178(4547):1405–1406. doi: 10.1038/1781405a0. [DOI] [PubMed] [Google Scholar]
- WILLOUGHBY D. S., GINZBURG Y., WATSON D. W. HOST-PARASITE RELATIONSHIPS AMONG GROUP A STREPTOCOCCI. I. HYALURONIC ACID PRODUCTION BY VIRULENT AND AVIRULENT STRAINS. J Bacteriol. 1964 Jun;87:1452–1456. doi: 10.1128/jb.87.6.1452-1456.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]