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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Neuropharmacology. 2013 May 2;0:96–105. doi: 10.1016/j.neuropharm.2013.04.040

Figure 4.

Figure 4

Effects of ketoprofen pretreatment during drug treatment on stress and Meth-induced hyperthermia. Meth (7.5 mg/kg q 2hrs, ×4 ip) or saline (1 mL/kg q 2hrs, ×4 ip) was administered to previously stressed or control rats. Some rats received ketoprofen (5 mg/kg, sc) 1 hr before each Meth or saline injection. Body temperatures were measured before and every hr after a Meth or saline injection. Larger arrows on the x-axis indicate the time of Meth or saline injections, while the smaller arrows indicate ketoprofen or vehicle injections. Meth significantly increased body temperature over time (*, p<0.001, two-way RM ANOVA) and prior exposure to 10 days of CUS significantly enhanced Meth-induced hyperthermia (#, p<0.001, Tukey’s post hoc test). Ketoprofen pretreatment had no significant effect on stress or Meth-induced hyperthermia. (n=6–10 for each group)