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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Neuropharmacology. 2013 May 2;0:96–105. doi: 10.1016/j.neuropharm.2013.04.040

Figure 6.

Figure 6

Effects of the EP1 receptor antagonist, SC-51089, pretreatment during drug treatment on stress and Meth-induced hyperthermia. Meth (7.5 mg/kg q 2hrs, ×4 ip) or saline (1 mL/kg q 2hrs, ×4 ip) was administered to previously stressed or control rats. Some rats received SC-51089 (5, 10 or 20 μg/kg, ip) 1 hr before each Meth or saline injection. Body temperatures were measured before and every hr after a Meth or saline injection. Larger arrows on the x-axis indicate the time of Meth or saline injections, while the smaller arrows indicate SC-51089 or vehicle injections. Stress+Meth significantly increased body temperature over time (*, p<0.001, two-way RM ANOVA). Pretreatment with SC-51089, at any dose, did not alter No Stress+Saline or Stress+Meth-induced hyperthermia. (n=5–7 for each group)