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. 1982 Jan;2(1):93–96. doi: 10.1128/mcb.2.1.93

Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation.

L H Graf Jr, L A Chasin
PMCID: PMC369757  PMID: 6287224

Abstract

Gamma ray-induced mutants of Chinese hamster ovary cells lacking dihydrofolate reductase activity were screened for DNA sequence changes at the locus specifying this activity by using a cloned cDNA probe. Two of nine mutants screened displayed an altered restriction fragment pattern suggesting the occurrence of DNA deletions or rearrangements.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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