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. 1982 Jun;2(6):694–700. doi: 10.1128/mcb.2.6.694

Nuclear Inheritance of Erythromycin Resistance in Human Cells: New Class of Mitochondrial Protein Synthesis Mutants

Claus-Jens Doersen 1,†, Eric J Stanbridge 1
PMCID: PMC369845  PMID: 14582164

Abstract

The characterization of two new erythromycin-resistant mutants of HeLa cells is described. The strains ERY2305 and ERY2309 both exhibited resistance to erythromycin in growth assays and cell-free mitochondrial protein synthesis assays. The erythromycin resistance phenotype could not be transferred by cybridization. The mutation appeared to be encoded in the nucleus and inherited as a recessive trait. These two mutants, therefore, represent a new class of erythromycin-resistant mutants in human cells that is distinct from the cytoplasmically inherited mutation in strain ERY2301 described previously.

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Selected References

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