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. 1982 Nov;2(11):1459–1462. doi: 10.1128/mcb.2.11.1459

Alterations of Gene Structure in Ethyl Methane Sulfonate-Induced Mutants of Mammalian Cells

Mark Meuth 1, Janet E Arrand 2
PMCID: PMC369950  PMID: 6298600

Abstract

To determine the types of alterations in gene structure induced by DNA-alkylating agents, we analyzed the restriction enzyme cleavage patterns of adenine phosphoribosyltransferase gene sequences in mutant strains of Chinese hamster ovary cells deficient in this enzyme. Base pair changes as detected by loss of restriction enzyme sites were found, but no major internal gene rearrangements could be detected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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