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. 1983 Aug;3(8):1527–1532. doi: 10.1128/mcb.3.8.1527

Tumor-promoting phorbol esters inhibit procollagen synthesis at a pretranslational level in JB-6 mouse epidermal cells.

M E Sobel, L D Dion, J Vuust, N H Colburn
PMCID: PMC369999  PMID: 6621538

Abstract

Collagen synthesis was inhibited in JB-6 mouse epidermal cells after exposure to 12-O-tetradecanoylphorbol-13-acetate under conditions leading to irreversible neoplastic transformation. In vitro translation and hybridization studies demonstrated a dramatic decrease in collagen mRNA in 12-O-tetradecanoylphorbol-13-acetate-treated cells, suggesting that the inhibition of collagen synthesis in response to 12-O-tetradecanoylphorbol-13-acetate is due to regulation at a pretranslational level.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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