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. 1982 Jun;69(6):1207–1211. doi: 10.1172/JCI110559

Inhibition of vascular permeability changes in rats by captopril.

J C Fantone, D Schrier, B Weingarten
PMCID: PMC370192  PMID: 6282931

Abstract

Systemic treatment of rats with captopril (50 mg/kg body wt per os), a specific competitive inhibitor of angiotensin l-converting enzyme, significantly inhibits vascular permeability changes induced by the intradermal injection of the vasoactive mediators histamine, bradykinin, serotonin, and compound 48/80. This effect of captopril is both dose- and time-dependent with approximately 60% inhibition of edema formation observed 7 h after captopril treatment (100 mg/kg body wt per os). The inhibitory effect of captopril on edema formation is temporally unrelated to the inhibition of serum angiotensin l-converting enzyme activity or serum prostaglandin E2 levels and is not inhibited by systemic treatment of rats with indomethacin. The data suggest that captopril may have potent antiinflammatory activity through as yet undefined mechanisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Clarke D. E., Wagner L. B., Wagner L. A. Studies on the mechanism of captopril induced hypotension in rats. Res Commun Chem Pathol Pharmacol. 1981 Jan;31(1):13–30. [PubMed] [Google Scholar]
  2. Cushman D. W., Ondetti M. A. Inhibitors of angiotensin-converting enzyme for treatment of hypertension. Biochem Pharmacol. 1980 Jul 1;29(13):1871–1877. doi: 10.1016/0006-2952(80)90096-9. [DOI] [PubMed] [Google Scholar]
  3. Erdos E. G., Yang H. Y. An enzyme in microsomal fraction of kidney that inactivates bradykinin. Life Sci. 1967 Mar 15;6(6):569–574. doi: 10.1016/0024-3205(67)90090-2. [DOI] [PubMed] [Google Scholar]
  4. Fantone J. C., Kunkel S. L., Ward P. A., Zurier R. B. Suppression by prostaglandin E1 of vascular permeability induced by vasoactive inflammatory mediators. J Immunol. 1980 Dec;125(6):2591–2596. [PubMed] [Google Scholar]
  5. Fitzpatrick F. A., Bundy G. L. Hapten mimic elicits antibodies recognizing prostaglandin E2. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2689–2693. doi: 10.1073/pnas.75.6.2689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fitzpatrick F. A., Gorman R. R., Mc Guire J. C., Kelly R. C., Wynalda M. A., Sun F. F. A radioimmunoassay for thromboxane B2. Anal Biochem. 1977 Sep;82(1):1–7. doi: 10.1016/0003-2697(77)90127-0. [DOI] [PubMed] [Google Scholar]
  7. Fitzpatrick F. A., Wynalda M. A. A rapid, solid phase radioimmunoassay for prostaglandin F2alpha and its main circulating metabolite. Anal Biochem. 1976 May 21;73(1):198–208. doi: 10.1016/0003-2697(76)90155-x. [DOI] [PubMed] [Google Scholar]
  8. Hinman L. M., Stevens C., Matthay R. A., Bernard J., Gee L. Angiotensin convertase activities in human alveolar macrophages: effects of cigarette smoking and sarcoidosis. Science. 1979 Jul 13;205(4402):202–203. doi: 10.1126/science.221980. [DOI] [PubMed] [Google Scholar]
  9. Kunkel S. L., Fantone J. C., Ward P. A., Zurier R. B. Modulation of inflammatory reactions by prostaglandins. Prog Lipid Res. 1981;20:633–640. doi: 10.1016/0163-7827(81)90118-1. [DOI] [PubMed] [Google Scholar]
  10. Kunkel S. L., Thrall R. S., Kunkel R. G., McCormick J. R., Ward P. A., Zurier R. B. Suppression of immune complex vasculitis in rats by prostaglandin. J Clin Invest. 1979 Nov;64(5):1525–1529. doi: 10.1172/JCI109611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Laffan R. J., Goldberg M. E., High J. P., Schaeffer T. R., Waugh M. H., Rubin B. Antihypertensive activity in rats for SQ 14,225, an orally active inhibitor of angiotensin I-converting enzyme. J Pharmacol Exp Ther. 1978 Feb;204(2):281–288. [PubMed] [Google Scholar]
  12. Lieberman J., Beutler E. Elevation of serum angiotensin-converting enzyme in Gaucher's disease. N Engl J Med. 1976 Jun 24;294(26):1442–1444. doi: 10.1056/NEJM197606242942609. [DOI] [PubMed] [Google Scholar]
  13. Lieberman J. Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis. Am J Med. 1975 Sep;59(3):365–372. doi: 10.1016/0002-9343(75)90395-2. [DOI] [PubMed] [Google Scholar]
  14. Lieberman J., Rea T. H. Serum angiotensin-converting enzyme in leprosy and coccidioidomycosis. Ann Intern Med. 1977 Oct;87(4):423–425. doi: 10.7326/0003-4819-87-4-422. [DOI] [PubMed] [Google Scholar]
  15. Rubin B., Antonaccio M. J., Horovitz Z. P. Captopril (SQ 14,225) (D-3-mercapto-2-methylpropranoyl-L-proline): a novel orally active inhibitor of angiotensin-converting enzyme and antihypertensive agent. Prog Cardiovasc Dis. 1978 Nov-Dec;21(3):183–194. doi: 10.1016/0033-0620(78)90024-5. [DOI] [PubMed] [Google Scholar]
  16. Schrier D. J., Ripani L. M., Katzenstein A. L., Moore V. L. Role of angiotensin-converting enzyme in Bacille Calmette-Guérin-induced granulomatous inflammation. Increased angiotensin-converting enzyme levels in lung lavage and suppression of inflammation with captopril. J Clin Invest. 1982 Mar;69(3):651–657. doi: 10.1172/JCI110492. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Swartz S. L., Williams G. H., Hollenberg N. K., Levine L., Dluhy R. G., Moore T. J. Captopril-induced changes in prostaglandin production: relationship to vascular responses in normal man. J Clin Invest. 1980 Jun;65(6):1257–1264. doi: 10.1172/JCI109788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Weinstock J. V., Ehrinpreis M. N., Boros D. L., Gee J. B. Effect of SQ 14225, an inhibitor of angiotensin I-converting enzyme, on the granulomatous response to Schistosoma mansoni eggs in mice. J Clin Invest. 1981 Apr;67(4):931–936. doi: 10.1172/JCI110142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Yang H. Y., Erdös E. G., Levin Y. Characterization of a dipeptide hydrolase (kininase II: angiotensin I converting enzyme). J Pharmacol Exp Ther. 1971 Apr;177(1):291–300. [PubMed] [Google Scholar]
  20. Zurier R. B., Quagliata F. Effect of prostaglandin E 1 on adjuvant arthritis. Nature. 1971 Dec 3;234(5327):304–305. doi: 10.1038/234304a0. [DOI] [PubMed] [Google Scholar]

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