Table 2.
Serial changes of 81 patients in biochemical parameters.
| d-Cinacalcet (N = 40) | VitD (N = 41) | p value | |
|---|---|---|---|
| Calcium (mg/dL) | |||
| Baseline | 9.9 ± 0.6 | 9.7 ± 0.6 | 0.065 |
| 3 months | 9.4 ± 0.7 a | 9.8 ± 0.6 | 0.004 |
| Reduction rate (%) | 5.6 ± 6.9 | −1.2 ± 6.0 | <0.0001 |
| 6 months | 9.6 ± 0.8 b | 10.0 ± 0.6 b | 0.018 |
| Reduction rate (%) | 3.5 ± 7.1 | −2.9 ± 5.1 | <0.0001 |
| Phosphorus (mg/dL) | |||
| Baseline | 5.9 ± 1.3 | 5.7 ± 0.8 | 0.373 |
| 3 months | 5.4 ± 1.2 a | 6.0 ± 1.0 | 0.032 |
| Reduction rate (%) | 5.8 ± 16.6 | −6.4 ± 18.4 | 0.003 |
| 6 months | 4.9 ± 0.9 bc | 5.7 ± 0.9 | <0.0001 |
| Reduction rate (%) | 14.3 ± 17.3 | −2.9 ± 20.5 | <0.0001 |
| Ca × P (mg2/dL2) | |||
| Baseline | 58.7 ± 15.0 | 54.8 ± 8.4 | 0.157 |
| 3 months | 51.0 ± 11.3 a | 58.4 ± 10.2 a | 0.003 |
| Reduction rate (%) | 10.5 ± 19.8 | −7.7 ± 20.2 | <0.0001 |
| 6 months | 46.9 ± 8.9 bc | 56.9 ± 9.0 | <0.0001 |
| Reduction rate (%) | 17.0 ± 20.0 | −5.7 ± 20.8 | <0.0001 |
| intact PTH (pg/mL) | |||
| Baseline | 1166.0 ± 469.3 | 1115.5 ± 436.2 | 0.618 |
| 3 months | 838.0 ± 418.4 a | 1152.7 ± 728.4 | 0.024 |
| Reduction rate (%) | 27.3 ± 21.1 | 3.7 ± 46.4 | 0.005 |
| 6 months | 679.8 ± 421.6 bc | 1021.9 ± 655.1 | 0.007 |
| Reduction rate (%) | 40.1 ± 26.5 | 7.7 ± 40.8 | <0.0001 |
| Albumin (mg/dL) | |||
| Baseline | 3.9 ± 0.2 | 3.9 ± 0.4 | 0.319 |
| 3 months | 3.8 ± 0.4 | 3.9 ± 0.2 | 0.104 |
| 6 months | 3.7 ± 0.4 | 3.7 ± 0.3 | 0.503 |
| Alkaline phosphate (U/L) | |||
| Baseline | 145.4 ± 87.6 | 133.2 ± 93.8 | 0.548 |
| 3 months | 139.7 ± 76.3 | 130.0 ± 92.0 | 0.609 |
| 6 months | 132.9 ± 90.6 | 130.2 ± 102.9 | 0.900 |
| Hemoglobin (mg/dL) | |||
| Baseline | 10.4 ± 1.4 | 10.4 ± 1.1 | 0.966 |
| 3 months | 10.8 ± 1.3 | 10.3 ± 1.1 | 0.109 |
| 6 months | 10.6 ± 1.2 | 10.4 ± 1.2 | 0.337 |
a Comparison between baseline and 3 months, p < 0.05; b Comparison between baseline and 6 months, p < 0.05; c Comparison between 3 months and 6 months, p < 0.05.