Abstract
Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 microM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Benveniste J., Camussi J., Polonsky J. Platelet-activating factor. Monogr Allergy. 1977;12:138–142. [PubMed] [Google Scholar]
- Benveniste J., Duval D., Arnoud B., Chrétien J. Libération du facteur activant les plaquettes (P.A.F.) par les macrophages alvéolaires. Nouv Presse Med. 1979 Jun 7;8(25):2071–2072. [PubMed] [Google Scholar]
- Benveniste J., Le Couedic J. P., Kamoun P. Letter: Aggregation of human platelets by platelet-activating factor. Lancet. 1975 Feb 8;1(7902):344–345. doi: 10.1016/s0140-6736(75)91264-7. [DOI] [PubMed] [Google Scholar]
- Benveniste J. Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils. Nature. 1974 Jun 7;249(457):581–582. doi: 10.1038/249581a0. [DOI] [PubMed] [Google Scholar]
- Benveniste J. Release of platelet-activating factor by peritoneal and alveolar macrophages. Monogr Allergy. 1979;14:138–141. [PubMed] [Google Scholar]
- Clark P. O., Hanahan D. J., Pinckard R. N. Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils. Biochim Biophys Acta. 1980 Feb 21;628(1):69–75. doi: 10.1016/0304-4165(80)90352-9. [DOI] [PubMed] [Google Scholar]
- Clark R. A., Gallin J. I., Kaplan A. P. Mediator release from basophil granulocytes in chronic myelogenous leukemia. J Allergy Clin Immunol. 1976 Dec;58(6):623–634. doi: 10.1016/0091-6749(76)90174-3. [DOI] [PubMed] [Google Scholar]
- Demopoulos C. A., Pinckard R. N., Hanahan D. J. Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators). J Biol Chem. 1979 Oct 10;254(19):9355–9358. [PubMed] [Google Scholar]
- Farr R. S., Cox C. P., Wardlow M. L., Jorgensen R. Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF). Clin Immunol Immunopathol. 1980 Mar;15(3):318–330. doi: 10.1016/0090-1229(80)90044-6. [DOI] [PubMed] [Google Scholar]
- Hanahan D. J., Demopoulos C. A., Liehr J., Pinckard R. N. Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine. J Biol Chem. 1980 Jun 25;255(12):5514–5516. [PubMed] [Google Scholar]
- Henson P. M., Pinckard R. N. Platelet activating factor (PAF). A possible direct mediator of anaphylaxis in the rabbit and a trigger for the vascular deposition of circulating immune complexes. Monogr Allergy. 1977;12:13–26. [PubMed] [Google Scholar]
- Henson P. M. Release of vasoactive amines from rabbit platelets induced by sensitized mononuclear leukocytes and antigen. J Exp Med. 1970 Feb;131(2):287–306. doi: 10.1084/jem.131.2.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levine S. P., Krentz L. S. Development of a radioimmunoassay for human platelet factor 4. Thromb Res. 1977 Nov;11(5):673–686. doi: 10.1016/0049-3848(77)90025-1. [DOI] [PubMed] [Google Scholar]
- Lewis R. A., Goetzl E. J., Wasserman S. I., Valone F. H., Rubin R. H., Austen K. F. The release of four mediators of immediate hypersensitivity from human leukemic basophils. J Immunol. 1975 Jan;114(1 Pt 1):87–92. [PubMed] [Google Scholar]
- Lotner G. Z., Lynch J. M., Betz S. J., Henson P. M. Human neutrophil-derived platelet activating factor. J Immunol. 1980 Feb;124(2):676–684. [PubMed] [Google Scholar]
- Lynch J. M., Lotner G. Z., Betz S. J., Henson P. M. The release of a platelet-activating factor by stimulated rabbit neutrophils. J Immunol. 1979 Sep;123(3):1219–1226. [PubMed] [Google Scholar]
- McManus L. M., Morley C. A., Levine S. P., Pinckard R. N. Platelet activating factor (PAF) induced release of platelet factor 4 (PF4) in vitro and during IgE anaphylaxis in the rabbit. J Immunol. 1979 Dec;123(6):2835–2841. [PubMed] [Google Scholar]
- Mencia-Huerta J. M., Benveniste J. Platelet-activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes. Eur J Immunol. 1979 May;9(5):409–415. doi: 10.1002/eji.1830090512. [DOI] [PubMed] [Google Scholar]
- O'Donnell M. C., Henson P. M., Fiedel B. A. Activation of human platelets by platelet activating factor (PAF) derived from sensitized rabbit basophils. Immunology. 1978 Dec;35(6):953–958. [PMC free article] [PubMed] [Google Scholar]
- Pinckard R. N., Farr R. S., Hanahan D. J. Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils. J Immunol. 1979 Oct;123(4):1847–1857. [PubMed] [Google Scholar]
- Tencé V., Polonsky J., Le Couedic J. P., Benveniste M. J. Release, purification, and characterization of platelet-activating factor (PAF). Biochimie. 1980;62(4):251–259. doi: 10.1016/s0300-9084(80)80399-3. [DOI] [PubMed] [Google Scholar]
- Valone F. H., Whitmer D. I., Pickett W. C., Austen K. F., Goetzl E. J. The immunological generation of a platelet-activating factor and a platet-lytic factor in the rat. Immunology. 1979 Aug;37(4):841–848. [PMC free article] [PubMed] [Google Scholar]