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. 1981 Apr;67(4):1111–1117. doi: 10.1172/JCI110124

Tolerance to the humoral and hemodynamic effects of caffeine in man.

D Robertson, D Wade, R Workman, R L Woosley, J A Oates
PMCID: PMC370671  PMID: 7009653

Abstract

Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinary catecholamines. Using a double-blind design, the effects of chronic caffeine administration on these same variables were assessed. Near complete tolerance, in terms of both humoral and hemodynamic variables, developed over the first 1-4 d of caffeine. No long-term effects of caffeine on blood pressure, heart rate, plasma renin activity, plasma catecholamines, or urinary catecholamines could be demonstrated. Discontinuation of caffeine ingestion after 7 d of administration did not result in a detectable withdrawal phenomenon relating to any of the variables assessed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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