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. 1981 May;67(5):1314–1323. doi: 10.1172/JCI110160

Abnormal coronary vascular response to exercise in dogs with severe right ventricular hypertrophy.

P A Murray, S F Vatner
PMCID: PMC370698  PMID: 6453133

Abstract

Measurements of right coronary artery blood flow, aortic and right ventricular (RV) pressures and heart rate were radiotelemetered during strenuous, spontaneous exercise in normal dogs and dogs with severe RV hypertrophy induced by chronic (5-6 mo) pulmonary artery stenosis. With fixed pulmonic stenosis, dogs with RV hypertrophy exhibited a decrease (P less than 0.01) in arterial pressure during exercise. Under these conditions, exercise increased right coronary artery blood flow and decreased right coronary vascular resistance less (P less than 0.05) in dogs with RV hypertrophy compared with normal. This attenuated response of right coronary artery blood flow of dogs with RV hypertrophy was not observed when arterial pressures remained at preexercise values during exercise. However, regardless of changes in arterial pressures during exercise, all dogs with RV hypertrophy demonstrated a striking postexercise coronary hyperemia (P less than 0.01), suggesting a perfusion deficit of the hypertrophied right ventricle during exercise. These results imply a fundamental defect in the ability of the coronary circulation of the severely hypertrophied right ventricle to provide sufficient nutrient supply in the face of elevated metabolic demands of exercise.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bache R. J., Vrobel T. R. Effects of exercise on blood flow in the hypertrophied heart. Am J Cardiol. 1979 Oct 22;44(5):1029–1033. doi: 10.1016/0002-9149(79)90240-6. [DOI] [PubMed] [Google Scholar]
  2. Belloni F. L., Phair R. D., Sparks H. V. The role of adenosine in prolonged vasodilation following flow-restricted exercise of canine skeletal muscle. Circ Res. 1979 Jun;44(6):759–766. doi: 10.1161/01.res.44.6.759. [DOI] [PubMed] [Google Scholar]
  3. Feigl E. O. Reflex parasympathetic coronary vasodilation elicited from cardiac receptors in the dog. Circ Res. 1975 Aug;37(2):175–182. doi: 10.1161/01.res.37.2.175. [DOI] [PubMed] [Google Scholar]
  4. Franklin D. E., Watson N. W., Pierson K. E., Van Citters R. L. Technique for radio telemetry of blood-flow velocity from unrestrained animals. Am J Med Electron. 1966;5(1):24–28. [PubMed] [Google Scholar]
  5. Gamble W. J., Phornphutkul C., Kumar A. E., Sanders G. L., Manasek F. J., Monroe R. G. Ventricular performance, coronary flow, and MVO 2 in aortic coarctation hypertrophy. Am J Physiol. 1973 Apr;224(4):877–883. doi: 10.1152/ajplegacy.1973.224.4.877. [DOI] [PubMed] [Google Scholar]
  6. Higgins C. B., Vatner S. F., Franklin D., Braunwald E. Effects of experimentally produced heart failure on the peripheral vascular response to severe exercise in conscious dogs. Circ Res. 1972 Aug;31(2):186–194. doi: 10.1161/01.res.31.2.186. [DOI] [PubMed] [Google Scholar]
  7. Holtz J., Restorff W. V., Bard P., Bassenge E. Transmural distribution of myocardial blood flow and of coronary reserve in canine left ventricular hypertrophy. Basic Res Cardiol. 1977 Mar-Jun;72(2-3):286–292. doi: 10.1007/BF01906375. [DOI] [PubMed] [Google Scholar]
  8. Johnson L. L., Sciacca R. R., Ellis K., Weiss M. B., Cannon P. J. Reduced left ventricular myocardial blood flow per unit mass in aortic stenosis. Circulation. 1978 Mar;57(3):582–590. doi: 10.1161/01.cir.57.3.582. [DOI] [PubMed] [Google Scholar]
  9. Malik A. B., Abe T., O'kane H., Geha A. S. Cardiac function, coronary flow, and oxygen consumption in stable left ventricular hypertrophy. Am J Physiol. 1973 Jul;225(1):186–191. doi: 10.1152/ajplegacy.1973.225.1.186. [DOI] [PubMed] [Google Scholar]
  10. Millard R. W., Higgins C. B., Franklin D., Vatner S. F. Regulation of the renal circulation during severe exercise in normal dogs and dogs with experimental heart failure. Circ Res. 1972 Dec;31(6):881–888. doi: 10.1161/01.res.31.6.881. [DOI] [PubMed] [Google Scholar]
  11. Morganroth M. L., Young E. W., Sparks H. V. Prostaglandin and histaminergic mediation of prolonged vasodilation after exercise. Am J Physiol. 1977 Jul;233(1):H27–H33. doi: 10.1152/ajpheart.1977.233.1.H27. [DOI] [PubMed] [Google Scholar]
  12. Mueller T. M., Marcus M. L., Kerber R. E., Young J. A., Barnes R. W., Abboud F. M. Effect of renal hypertension and left ventricular hypertrophy on the coronary circulation in dogs. Circ Res. 1978 Apr;42(4):543–549. doi: 10.1161/01.res.42.4.543. [DOI] [PubMed] [Google Scholar]
  13. Murray P. A., Baig H., Fishbein M. C., Vatner S. F. Effects of exerimental right ventricular hypertrophy on myocardial blood flow in conscious dogs. J Clin Invest. 1979 Aug;64(2):421–427. doi: 10.1172/JCI109478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Murray P. A., Vatner S. F. Fractional contributions of the right and left coronary arteries to perfusion of normal and hypertrophied right ventricles of conscious dogs. Circ Res. 1980 Aug;47(2):190–200. doi: 10.1161/01.res.47.2.190. [DOI] [PubMed] [Google Scholar]
  15. Murray P. A., Vatner S. F. Reduction of maximal coronary vasodilator capacity in conscious dogs with severe right ventricular hypertrophy. Circ Res. 1981 Jan;48(1):25–33. doi: 10.1161/01.res.48.1.25. [DOI] [PubMed] [Google Scholar]
  16. Murray P. A., Vatner S. F. alpha-Adrenoceptor attenuation of the coronary vascular response to severe exercise in the conscious dog. Circ Res. 1979 Nov;45(5):654–660. doi: 10.1161/01.res.45.5.654. [DOI] [PubMed] [Google Scholar]
  17. O'Keefe D. D., Hoffman J. I., Cheitlin R., O'Neill M. J., Allard J. R., Shapkin E. Coronary blood flow in experimental canine left ventricular hypertrophy. Circ Res. 1978 Jul;43(1):43–51. doi: 10.1161/01.res.43.1.43. [DOI] [PubMed] [Google Scholar]
  18. Pagani M., Vatner S. F., Baig H., Braunwald E. Initial myocardial adjustments to brief periods of ischemia and reperfusion in the conscious dog. Circ Res. 1978 Jul;43(1):83–92. doi: 10.1161/01.res.43.1.83. [DOI] [PubMed] [Google Scholar]
  19. Patrick T. A., Vatner S. F., Kemper W. S., Franklin D. Telemetry of left ventricular diameter and pressure measurements from unrestrained animals. J Appl Physiol. 1974 Aug;37(2):276–281. doi: 10.1152/jappl.1974.37.2.276. [DOI] [PubMed] [Google Scholar]
  20. Pyle R. L., Lowensohn H. S., Khouri E. M., Gregg D. E., Patterson D. F. Left circumflex coronary artery hemodynamics in conscious dogs with congenital subaortic stenosis. Circ Res. 1973 Jul;33(1):34–38. doi: 10.1161/01.res.33.1.34. [DOI] [PubMed] [Google Scholar]
  21. Rembert J. C., Kleinman L. H., Fedor J. M., Wechsler A. S., Greenfield J. C., Jr Myocardial blood flow distribution in concentric left ventricular hypertrophy. J Clin Invest. 1978 Aug;62(2):379–386. doi: 10.1172/JCI109139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Vatner S. F., Franklin D., VanCitters R. L. Simultaneous comparison and calibration of the Doppler and electromagnetic flowmeters. J Appl Physiol. 1970 Dec;29(6):907–910. doi: 10.1152/jappl.1970.29.6.907. [DOI] [PubMed] [Google Scholar]
  23. Vatner S. F., Higgins C. B., White S., Patrick T., Franklin D. The peripheral vascular response to severe exercise in untethered dogs before and after complete heart block. J Clin Invest. 1971 Sep;50(9):1950–1960. doi: 10.1172/JCI106687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Vatner S. F., McRitchie R. J., Maroko P. R., Patrick T. A., Braunwald E. Effects of catecholamines, exercise, and nitroglycerin on the normal and ischemic myocardium in conscious dogs. J Clin Invest. 1974 Sep;54(3):563–575. doi: 10.1172/JCI107793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. WEST J. W., MERCKER H., WENDEL H., FOLTZ E. L. Effects of renal hypertension on coronary blood flow, cardiac oxygen consumption and related circulatory dynamics of the dog. Circ Res. 1959 May;7(3):476–485. doi: 10.1161/01.res.7.3.476. [DOI] [PubMed] [Google Scholar]

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