Abstract
Obese subjects have elevated adipose tissue lipoprotein lipase activity per fat cell when compared with lean control subjects. This enzyme, which is rate limiting for the uptake and storage of lipoprotein triglyceride in adipose tissue, has been shown to be further elevated in a group of previously obese subjects who had been weight stable at a reduced weight for 4-28 mo. In the present prospective study of eight obese subjects, adipose tissue lipoprotein lipase activity was demonstrated to increase after weight stabilization at a reduced weight (0.33 mU/10(6) cells). In three subjects who lost weight and subsequently regained their lost weight, the enzyme activity increased after weight loss and then returned toward the original basal level with weight gain. One subject who maintained his weight loss for 10 mo. continued to have an elevated level of enzyme activity. Because adipose tissue lipoprotein lipase activity does not "normalize" after weight loss, we hypothesize that this enzyme may play a counterregulatory role in resisting deviation from a "set point" for fat mass or fat cell size and thereby predispose to reattainment of the original obese state.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bagdade J. D., Bierman E. L., Porte D., Jr The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J Clin Invest. 1967 Oct;46(10):1549–1557. doi: 10.1172/JCI105646. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Björntorp P. Studies on adipose tissue from obese patients with or without diabetes mellitus. II. Basal and insulin-stimulated glucose metabolism. Acta Med Scand. 1966 Feb;179(2):229–234. doi: 10.1111/j.0954-6820.1966.tb05452.x. [DOI] [PubMed] [Google Scholar]
- Blanchette-Mackie E. J., Scow R. O. Sites of lipoprotein lipase activity in adipose tissue perfused with chylomicrons. Electron microscope cytochemical study. J Cell Biol. 1971 Oct;51(1):1–25. doi: 10.1083/jcb.51.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bray G. A., Campfield L. A. Metabolic factors in the control of energy stores. Metabolism. 1975 Jan;24(1):99–117. doi: 10.1016/0026-0495(75)90011-6. [DOI] [PubMed] [Google Scholar]
- Cleary M. P., Vasselli J. R., Greenwood M. R. Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia. Am J Physiol. 1980 Mar;238(3):E284–E292. doi: 10.1152/ajpendo.1980.238.3.E284. [DOI] [PubMed] [Google Scholar]
- Goldberg A. P., Chait A., Brunzell J. D. Postprandial adipose tissue lipoprotein lipase activity in primary hypertriglyceridemia. Metabolism. 1980 Mar;29(3):223–229. doi: 10.1016/0026-0495(80)90063-3. [DOI] [PubMed] [Google Scholar]
- Goldberg A., Sherrard D. J., Brunzell J. D. Adipose tissue lipoprotein lipase in chronic hemodialysis: role in plasma triglyceride metabolism. J Clin Endocrinol Metab. 1978 Dec;47(6):1173–1182. doi: 10.1210/jcem-47-6-1173. [DOI] [PubMed] [Google Scholar]
- Goldrick R. B. Morphological changes in the adipocyte during fat deposition and mobilization. Am J Physiol. 1967 Apr;212(4):777–782. doi: 10.1152/ajplegacy.1967.212.4.777. [DOI] [PubMed] [Google Scholar]
- Guy-Grand B., Bigorie B. Effect of fat cell size, restrictive diet and diabetes on lipoprotein lipase release by human adipose tissue. Horm Metab Res. 1975 Nov;7(6):471–475. doi: 10.1055/s-0028-1093706. [DOI] [PubMed] [Google Scholar]
- Knittle J. L., Ginsberg-Fellner F. Effect of weight reduction on in vitro adipose tissue lipolysis and cellularity in obese adolescents and adults. Diabetes. 1972 Jun;21(6):754–761. doi: 10.2337/diab.21.6.754. [DOI] [PubMed] [Google Scholar]
- Lew E. A., Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis. 1979;32(8):563–576. doi: 10.1016/0021-9681(79)90119-x. [DOI] [PubMed] [Google Scholar]
- Lithell H., Boberg J., Hellsing K., Waern U. Lipoprotein-lipase activity in subcutaneous, adipose tissue in healthy subjects: variation of activity in a population of 60-year-old men. Ups J Med Sci. 1978;83(1):45–52. doi: 10.3109/03009737809179112. [DOI] [PubMed] [Google Scholar]
- Nikkilä E. A., Taskinen M. R., Kekki M. Relation of plasma high-density lipoprotein cholesterol to lipoprotein-lipase activity in adipose tissue and skeletal muscle of man. Atherosclerosis. 1978 Apr;29(4):497–501. doi: 10.1016/0021-9150(78)90178-8. [DOI] [PubMed] [Google Scholar]
- Olefsky J., Reaven G. M., Farquhar J. W. Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. J Clin Invest. 1974 Jan;53(1):64–76. doi: 10.1172/JCI107560. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Persson B., Hood B., Angervall G. Effects of prolonged fast on lipoprotein lipase activity eluted from human adipose tissue. Acta Med Scand. 1970 Sep;188(3):225–229. doi: 10.1111/j.0954-6820.1970.tb08030.x. [DOI] [PubMed] [Google Scholar]
- Pykälistö O. J., Smith P. H., Brunzell J. D. Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity. J Clin Invest. 1975 Nov;56(5):1108–1117. doi: 10.1172/JCI108185. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STUNKARD A., McLAREN-HUME M. The results of treatment for obesity: a review of the literature and report of a series. AMA Arch Intern Med. 1959 Jan;103(1):79–85. doi: 10.1001/archinte.1959.00270010085011. [DOI] [PubMed] [Google Scholar]
- Salans L. B., Cushman S. W., Weismann R. E. Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients. J Clin Invest. 1973 Apr;52(4):929–941. doi: 10.1172/JCI107258. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwartz R. S., Brunzell J. D. Increased adipose-tissue lipoprotein-lipase activity in moderately obese men after weight reduction. Lancet. 1978 Jun 10;1(8076):1230–1231. doi: 10.1016/s0140-6736(78)92465-0. [DOI] [PubMed] [Google Scholar]
- Sjöström L., Björntorp P., Vrána J. Microscopic fat cell size measurements on frozen-cut adipose tissue in comparison with automatic determinations of osmium-fixed fat cells. J Lipid Res. 1971 Sep;12(5):521–530. [PubMed] [Google Scholar]
- Taskinen M. R., Nikkilä E. A. Effects of caloric restriction on lipid metabolism in man: changes of tissue lipoprotein lipase activities and of serum lipoproteins. Atherosclerosis. 1979 Mar;32(3):289–299. doi: 10.1016/0021-9150(79)90172-2. [DOI] [PubMed] [Google Scholar]
- Taskinen M. R., Nikkilä E. A. Lipoprotein lipase activity in adipose tissue and in postheparin plasma in human obesity. Acta Med Scand. 1977;202(5):399–408. doi: 10.1111/j.0954-6820.1977.tb16851.x. [DOI] [PubMed] [Google Scholar]
- Wing R. R., Jeffery R. W. Outpatient treatments of obesity: a comparison of methodology and clinical results. Int J Obes. 1979;3(3):261–279. [PubMed] [Google Scholar]