Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1981 Jun;67(6):1797–1800. doi: 10.1172/JCI110220

Immunoglobulin G heavy chain (Gm) allotypes in multiple sclerosis.

J P Pandey, J M Goust, J P Salier, H H Fudenberg
PMCID: PMC370759  PMID: 6787085

Abstract

Serum samples from 70 Caucasian patients with multiple sclerosis were typed for nine Gm markers. Significant association was found with the Gm 1,17;21 phenotype, and the relative risk for individuals with this phenotype was calculated at 3.6. The data indicate that Caucasians positive for Gm 1,17;21 are almost four times more likely to develop multiple sclerosis than those without this phenotype.

Full text

PDF
1797

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Kassab S., Dittmann L., Olesen H. IgG subclasses, barrier function for albumin and production of immunoglobulin G in the central nervous system. Acta Neurol Scand. 1979 Sep;60(3):129–139. doi: 10.1111/j.1600-0404.1979.tb02960.x. [DOI] [PubMed] [Google Scholar]
  2. Antel J. P., Arnason B. G., Medof M. E. Suppressor cell function in multiple sclerosis: correlation with clinical disease activity. Ann Neurol. 1979 Apr;5(4):338–342. doi: 10.1002/ana.410050406. [DOI] [PubMed] [Google Scholar]
  3. Berman P. W., Patrick J. Linkage between the frequency of muscular weakness and loci that regulate immune responsiveness in murine experimental myasthenia gravis. J Exp Med. 1980 Sep 1;152(3):507–520. doi: 10.1084/jem.152.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bodmer W. F. The HLA system and disease. The Oliver Sharpey Lecture 1979. J R Coll Physicians Lond. 1980 Jan;14(1):43–50. [PMC free article] [PubMed] [Google Scholar]
  5. Brautbar C., Alter M., Kahana E. HLA antigens in multiple sclerosis. Neurology. 1976 Jun;26(6 Pt 2):50–53. doi: 10.1212/wnl.26.6_part_2.50. [DOI] [PubMed] [Google Scholar]
  6. Croce C. M., Shander M., Martinis J., Cicurel L., D'Ancona G. G., Dolby T. W., Koprowski H. Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3416–3419. doi: 10.1073/pnas.76.7.3416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dupont B., Lisak R. P., Jersild C., Hansen J. A., Silberberg D. H., Whitsett C., Zweiman B., Ciongoli K. HLA antigens in black American patients with multiple sclerosis. Transplant Proc. 1977 Mar;9(1 Suppl 1):181–185. [PubMed] [Google Scholar]
  8. Goust J. M., Hoffman P. M., Pryjma J., Hogan E. L., Fudenberg H. H. Defective immunoregulation in multiple sclerosis. Ann Neurol. 1980 Nov;8(5):526–533. doi: 10.1002/ana.410080510. [DOI] [PubMed] [Google Scholar]
  9. Griffing W. L., Moore S. B., Luthra H. S., McKenna C. H., Fathman C. G. Associations of antibodies to native DNA with HLA-DRw3. A possible major histocompatibility complex-linked human immune response gene. J Exp Med. 1980 Aug 1;152(2 Pt 2):319s–325s. [PubMed] [Google Scholar]
  10. Huddlestone J. R., Oldstone M. B. T suppressor (TG) lymphocytes fluctuate in parallel with changes in the clinical course of patients with multiple sclerosis. J Immunol. 1979 Oct;123(4):1615–1618. [PubMed] [Google Scholar]
  11. Johnson W. E., Kohn P. H., Steinberg A. G. Population genetics of the human allotypes Gm, Inv, and A2m. Clin Immunol Immunopathol. 1977 Jan;7(1):97–113. doi: 10.1016/0090-1229(77)90034-4. [DOI] [PubMed] [Google Scholar]
  12. Laurenzi M. A., Mavra M., Kam-Hansen S., Link H. Oligoclonal IgG and free chains in multiple sclerosis demonstrated by thin-layer polyacrylamide gel isoelectric focusing and immunofixation. Ann Neurol. 1980 Sep;8(3):241–247. doi: 10.1002/ana.410080304. [DOI] [PubMed] [Google Scholar]
  13. Mackay R. P., Myrianthopoulos N. C. Multiple sclerosis in twins and their relatives. Arch Neurol. 1966 Nov;15(5):449–462. doi: 10.1001/archneur.1966.00470170003001. [DOI] [PubMed] [Google Scholar]
  14. Norrby E., Link H., Olsson J. E., Panelius M., Salmi A., Vandvik B. Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis. Infect Immun. 1974 Oct;10(4):688–694. doi: 10.1128/iai.10.4.688-694.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Palmer D. L., Minard B. J., Cawley L. P. Letter: IgG subgroups in cerebrospinal fluid in multiple sclerosis. N Engl J Med. 1976 Feb 19;294(8):447–448. doi: 10.1056/nejm197602192940821. [DOI] [PubMed] [Google Scholar]
  16. Paul W. E., Benacerraf B. Functional specificity of thymus- dependent lymphocytes. Science. 1977 Mar 25;195(4284):1293–1300. doi: 10.1126/science.320663. [DOI] [PubMed] [Google Scholar]
  17. Reinherz E. L., Weiner H. L., Hauser S. L., Cohen J. A., Distaso J. A., Schlossman S. F. Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies. N Engl J Med. 1980 Jul 17;303(3):125–129. doi: 10.1056/NEJM198007173030303. [DOI] [PubMed] [Google Scholar]
  18. Rose A. S., Ellison G. W., Myers L. W., Tourtellotte W. W. Criteria for the clinical diagnosis of multiple sclerosis. Neurology. 1976 Jun;26(6 Pt 2):20–22. doi: 10.1212/wnl.26.6_part_2.20. [DOI] [PubMed] [Google Scholar]
  19. Saito S., Naito S., Kawanami S., Kurowa Y. HLA studies on multiple sclerosis in Japan. Neurology. 1976 Jun;26(6 Pt 2):49–49. doi: 10.1212/wnl.26.6_part_2.49. [DOI] [PubMed] [Google Scholar]
  20. Santoli D., Moretta L., Lisak R., Gilden D., Koprowski H. Imbalances in T cell subpopulations in multiple sclerosis patients. J Immunol. 1978 Apr;120(4):1369–1371. [PubMed] [Google Scholar]
  21. Stendahl-Brodin L., Link H., Möller E., Norrby E. Genetic basis of multiple sclerosis: HLA antigens, disease progression, and oligoclonal IgG in CSF. Acta Neurol Scand. 1979 Jun;59(6):297–308. doi: 10.1111/j.1600-0404.1979.tb02940.x. [DOI] [PubMed] [Google Scholar]
  22. Tiwari J. L., Hodge S. E., Terasaki P. I., Spence M. A. HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees. Am J Hum Genet. 1980 Jan;32(1):103–111. [PMC free article] [PubMed] [Google Scholar]
  23. Tourtellotte W. W., Ma B. I. Multiple sclerosis: the blood-brain-barrier and the measurement of de novo central nervous system IgG synthesis. Neurology. 1978 Sep;28(9 Pt 2):76–83. doi: 10.1212/wnl.28.9_part_2.76. [DOI] [PubMed] [Google Scholar]
  24. Vandvik B., Natvig J. B., Wiger D. IgG1 subclass restriction of oligoclonal IgG from cerebrospinal fluids and brain extracts in patients with multiple sclerosis and subacute encephalitides. Scand J Immunol. 1976;5(4):427–436. doi: 10.1111/j.1365-3083.1976.tb00297.x. [DOI] [PubMed] [Google Scholar]
  25. Vyas G. N., Fudenberg H. H., Pretty H. M., Gold E. R. A new rapid method for genetic typing of human immunoglobulins. J Immunol. 1968 Feb;100(2):274–279. [PubMed] [Google Scholar]
  26. WOOLF B. On estimating the relation between blood group and disease. Ann Hum Genet. 1955 Jun;19(4):251–253. doi: 10.1111/j.1469-1809.1955.tb01348.x. [DOI] [PubMed] [Google Scholar]
  27. Wells J. V., Fudenberg H. H., MacKay I. R. RElation of the human antibody response to flagellin to GM genotype. J Immunol. 1971 Dec;107(6):1505–1511. [PubMed] [Google Scholar]
  28. Whittingham S., Mathews J. D., Schanfield M. S., Matthews J. V., Tait B. D., Morris P. J., Mackay I. R. Interactive effect of Gm allotypes and HLA-B locus antigens on the human antibody response to a bacterial antigen. Clin Exp Immunol. 1980 Apr;40(1):8–15. [PMC free article] [PubMed] [Google Scholar]
  29. Whittingham S., Mathews J. D., Schanfield M. S., Tait B. D., Mackay I. R. Interaction of HLA and Gm in autoimmune chronic active hepatitis. Clin Exp Immunol. 1981 Jan;43(1):80–86. [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES