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. Author manuscript; available in PMC: 2013 Jul 10.
Published in final edited form as: Hepatology. 2009 Dec;50(6):1738–1749. doi: 10.1002/hep.23211

Figure 5.

Figure 5

Mean collagen content (± SEM) at different time points for the 535 patients in the study by randomization strata. The median interval between baseline biopsy and biopsy 2 was 36.8 months for the breakthrough/relapse patients, 25.3 months for the end of lead-in patients and 21.4 months for the express patients. Mean collagen in biopsy 2 was significantly greater than in the baseline biopsy for lead-in nonresponders (p<0.0001) breakthrough/relapse patients (p=0.0029), but biopsy 3 was not statistically significantly greater than biopsy 2 for either group. Express patients had significantly more collagen in the baseline biopsy than lead-in and breakthrough/relapse patients (p<0.0001), but the differences between baseline biopsy, biopsy 2 and biopsy 3 for express patients were not statistically significant.