Abstract
Organs that are rich in collagen such as liver, lungs, and bone are frequently sites of tumor cell metastasis. In this study, we have found that cultured tumor cells of human and rat origin migrated unidirectionally in response to collagen in vitro. Synthetic di- and tri-peptides that contained amino acid sequences found frequently in the collagen helix caused similar effects. These results are consistent with the hypothesis that collagen or collagen fragments released during connective tissue remodeling may be important in tumor cell metastasis.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cailleau R., Young R., Olivé M., Reeves W. J., Jr Breast tumor cell lines from pleural effusions. J Natl Cancer Inst. 1974 Sep;53(3):661–674. doi: 10.1093/jnci/53.3.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chung E., Miller E. J. Collagen polymorphism: characterization of molecules with the chain composition (alpha 1 (3)03 in human tissues. Science. 1974 Mar;183(130):1200–1201. doi: 10.1126/science.183.4130.1200. [DOI] [PubMed] [Google Scholar]
- Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
- Orr F. W., Varani J., Gondek M. D., Ward P. A., Mundy G. R. Partial characterization of a bone-derived chemotactic factor for tumor cells. Am J Pathol. 1980 Apr;99(1):43–52. [PMC free article] [PubMed] [Google Scholar]
- Orr W., Varani J., Gondex M. K., Ward P. A., Mundy G. R. Chemotactic responses of tumor cells to products of resorbing bone. Science. 1979 Jan 12;203(4376):176–179. doi: 10.1126/science.569363. [DOI] [PubMed] [Google Scholar]
- Orr W., Varani J., Ward P. A. Characteristics of the chemotactic response of neoplastic cells to a factor derived from the fifth component of complement. Am J Pathol. 1978 Nov;93(2):405–422. [PMC free article] [PubMed] [Google Scholar]
- Postlethwaite A. E., Kang A. H. Collagen-and collagen peptide-induced chemotaxis of human blood monocytes. J Exp Med. 1976 Jun 1;143(6):1299–1307. doi: 10.1084/jem.143.6.1299. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Postlethwaite A. E., Seyer J. M., Kang A. H. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci U S A. 1978 Feb;75(2):871–875. doi: 10.1073/pnas.75.2.871. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Romualdez A. G., Jr, Ward P. A. A unique complement derived chemotactic factor for tumor cells. Proc Natl Acad Sci U S A. 1975 Oct;72(10):4128–4132. doi: 10.1073/pnas.72.10.4128. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Romualdez A. G., Ward P. A., Torikata T. Relationship between the C5 peptides chemotactic for leukocytes and tumor cells. J Immunol. 1976 Nov;117(5 PT2):1762–1766. [PubMed] [Google Scholar]
- Seyer J. M., Hutcheson E. T., Kang A. H. Collagen polymorphism in idiopathic chronic pulmonary fibrosis. J Clin Invest. 1976 Jun;57(6):1498–1507. doi: 10.1172/JCI108420. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sykes B., Puddle B., Francis M., Smith R. The estimation of two collagens from human dermis by interrupted gel electrophoresis. Biochem Biophys Res Commun. 1976 Oct 18;72(4):1472–1480. doi: 10.1016/s0006-291x(76)80180-5. [DOI] [PubMed] [Google Scholar]
- WARD P. A., COCHRANE C. G., MUELLER-EBERHARD H. J. THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO. J Exp Med. 1965 Aug 1;122:327–346. doi: 10.1084/jem.122.2.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yoneda T., Mundy G. R. Monocytes regulate osteoclast-activating factor production by releasing prostaglandins. J Exp Med. 1979 Aug 1;150(2):338–350. doi: 10.1084/jem.150.2.338. [DOI] [PMC free article] [PubMed] [Google Scholar]