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Experimental designs. (A) Experiment 1 was designed to investigate the effect of the PAR-1 agonist, SFLLRN. (B) Experiment 2 was designed to evaluate the dose-dependent effect of SCH79797. (C) Experiment 3 was designed to show the effects of SCH79797 treatment. (D) Experiment 4 was designed to explore the mechanism of SCH79797 treatment. IP, intraperitoneally injection; IV, intravenously injection; IF, immunofluorescence staining; WB, Western blot.
