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. 1982 Jan;69(1):226–230. doi: 10.1172/JCI110434

Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy.

S L Sacks, T C Merigan, J Kaminska, I H Fox
PMCID: PMC371186  PMID: 7054240

Abstract

To assess for possible inhibition of cellular transmethylation during adenine arabinoside (ara-A) therapy, S-adenosylhomocysteine hydrolase activity was analyzed in 10 patients with chronic hepatitis B virus infection. In six patients receiving ara-A, enzyme activity was suppressed to 0-2% of control erythrocyte enzyme activity. This decrease in enzyme activity was evident within 4 h of starting the drug infusion and continued for 7 d after cessation of therapy. S-adenosylhomocysteine hydrolase activity of peripheral mononuclear cells was also measured in two patients receiving ara-A. Suppression to as low as 3.5% of pretreatment levels was found; however, marked fluctuations with partial return of enzyme activity during therapy was also observed in mononuclear cells. Inhibition of an enzyme involved in transmethylation reactions was observed in patients during ara-A therapy. This could contribute to the side effects and antiviral properties of ara-A.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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