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. 2013 Jun 14;62(7):2481–2491. doi: 10.2337/db12-1273

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 4. — Multiple biological correlations in type 1 diabetes. Two-dimensional graphical representation of the Spearman ρ nonparametric correlation matrix among the studied variables. The presence of a significant correlation between two variables is expressed by means of a red (negative correlation) or blue (positive correlation) ellipse, and an empty circle refers to a nonsignificant correlation. The color intensity and thickness of each ellipse are proportional to the correlation value (see graphic legend for numeric values). Correlation analysis, performed on all parameters analyzed, revealed a distinctive immune/metabolic profile for controls and new-onset diabetic patients. A negative correlation between sLepR and β-cell residual fasting C-pep secretion (r = −0.39, P < 0.001) was observed in individuals affected by type 1 diabetes but not in controls. #Absolute number of indicated cell populations with respect to the number of leukocytes; %percentage of indicated cell populations with respect to the number of leukocytes.