Table 2.
Risk factors |
---|
Dose and duration of therapy |
Intra-articular administration |
Polymorphisms in VEGF, GR, 11β-HSD2, COL2A1, PAI1, P-glycoprotein |
Underlying disorders: renal insufficiency, transplantation, graft vs. host disease, inflammatory bowel disease, HIV, acute lymphoblastic leukemia |
Dexamethasone causes greater skeletal complications than prednisone |
VEGF vascular endothelial growth factor, GR glucocorticoid receptor, 11β-HSD2 11β-hydroxysteroid dehydrogenase type2, COL2A1 collagen type II, PAI1 plasminogen activator inhibitor 1, HIV human immunodeficiency virus