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. 1980 Jan;65(1):5–14. doi: 10.1172/JCI109659

Alpha Adrenergic Vasoconstriction and Nitroglycerin Vasodilation of Large Coronary Arteries in the Conscious Dog

Stephen F Vatner 1,2, Massimo Pagani 1,2, W Thomas Manders 1,2, Ares D Pasipoularides 1,2
PMCID: PMC371334  PMID: 6765959

Abstract

The effects of methoxamine and nitroglycerin on measurements of large vessel (left circumflex) coronary dimensions were examined in eight conscious dogs using an ultrasonic dimension gauge, and total coronary resistance was calculated from measurements of arterial pressure and coronary blood flow. Methoxamine (50 μg/kg per min), after transiently increasing left circumflex coronary dimensions, induced sustained reductions in left circumflex diameter (9±2%) and external (18±4%) and internal (27±5%) cross-sectional areas, at a time when mean arterial pressure rose by 65±5%, left ventricular dP/dt had decreased only slightly, and heart rate and mean coronary blood flow remained at control levels. Calculated large vessel and total coronary resistances rose similarly, i.e., by 108±29 and 92±14%, respectively. Methoxamine reduced coronary arterial wall stiffness from control at comparable stress levels, although at any common radius, wall stiffness was augmented substantially. Nitroglycerin (25 μg/kg) induced an initial decrease in coronary dimensions along with the fall in arterial pressure. However, left circumflex coronary dimensions then rose, reaching a maximum 5 min later at a time when left circumflex coronary blood flow was reduced and heart rate and left ventricular dP/dt were at control levels. At this time, significantly different effects were observed on large vessel coronary resistance, which fell by 18±2%, and on total coronary resistance, which rose by 11±4%. Thus, in the conscious dog, large coronary vessels not only react passively to changes in aortic pressure but also undergo substantial active changes. Alpha adrenergic stimulation is sufficiently powerful to reduce cross-sectional area, despite the opposing elevation of distending pressure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen M. V., Kirk E. S. Differential response of large and small coronary arteries to nitroglycerin and angiotensin. Autoregulation and tachyphylaxis. Circ Res. 1973 Oct;33(4):445–453. doi: 10.1161/01.res.33.4.445. [DOI] [PubMed] [Google Scholar]
  2. Cox R. H. Passive mechanics and connective tissue composition of canine arteries. Am J Physiol. 1978 May;234(5):H533–H541. doi: 10.1152/ajpheart.1978.234.5.H533. [DOI] [PubMed] [Google Scholar]
  3. Douglas J. E., Greenfield J. C., Jr Epicardial coronary artery compliance in the dog. Circ Res. 1970 Dec;27(6):921–929. doi: 10.1161/01.res.27.6.921. [DOI] [PubMed] [Google Scholar]
  4. Fam W. M., McGregor M. Effect of nitroglycerin and dipyridamole on regional coronary resistance. Circ Res. 1968 May;22(5):649–659. doi: 10.1161/01.res.22.5.649. [DOI] [PubMed] [Google Scholar]
  5. Feigl E. O. Sympathetic control of coronary circulation. Circ Res. 1967 Feb;20(2):262–271. doi: 10.1161/01.res.20.2.262. [DOI] [PubMed] [Google Scholar]
  6. Hillis L. D., Braunwald E. Coronary-artery spasm. N Engl J Med. 1978 Sep 28;299(13):695–702. doi: 10.1056/NEJM197809282991305. [DOI] [PubMed] [Google Scholar]
  7. Holtz J., Mayer E., Bassenge E. Demonstration of alpha-adrenergic coronary control in different layers of canine myocardium by regional myocardial sympathectomy. Pflugers Arch. 1977 Dec 12;372(2):187–194. doi: 10.1007/BF00585335. [DOI] [PubMed] [Google Scholar]
  8. Kelley K. O., Feigl E. O. Segmental alpha-receptor-mediated vasoconstriction in the canine coronary circulation. Circ Res. 1978 Dec;43(6):908–917. doi: 10.1161/01.res.43.6.908. [DOI] [PubMed] [Google Scholar]
  9. Maseri A., L'Abbate A., Baroldi G., Chierchia S., Marzilli M., Ballestra A. M., Severi S., Parodi O., Biagini A., Distante A. Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of "preinfarction" angina. N Engl J Med. 1978 Dec 7;299(23):1271–1277. doi: 10.1056/NEJM197812072992303. [DOI] [PubMed] [Google Scholar]
  10. Mudge G. H., Jr, Grossman W., Mills R. M., Jr, Lesch M., Braunwald E. Reflex increase in coronary vascular resistance in patients with ischemic heart disease. N Engl J Med. 1976 Dec 9;295(24):1333–1337. doi: 10.1056/NEJM197612092952401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. PRINZMETAL M., KENNAMER R., MERLISS R., WADA T., BOR N. Angina pectoris. I. A variant form of angina pectoris; preliminary report. Am J Med. 1959 Sep;27:375–388. doi: 10.1016/0002-9343(59)90003-8. [DOI] [PubMed] [Google Scholar]
  12. Pagani M., Baig H., Sherman A., Manders W. T., Quinn P., Patrick T., Franklin D., Vatner S. F. Measurement of multiple simultaneous small dimensions and study of arterial pressure-dimension relations in conscious animals. Am J Physiol. 1978 Nov;235(5):H610–H617. doi: 10.1152/ajpheart.1978.235.5.H610. [DOI] [PubMed] [Google Scholar]
  13. Pagani M., Mirsky I., Baig H., Manders W. T., Kerkhof P., Vatner S. F. Effects of age on aortic pressure-diameter and elastic stiffness-stress relationships in unanesthetized sheep. Circ Res. 1979 Mar;44(3):420–429. doi: 10.1161/01.res.44.3.420. [DOI] [PubMed] [Google Scholar]
  14. Patel D. J., Janicki J. S. Static elastic properties of the left coronary circumflex artery and the common carotid artery in dogs. Circ Res. 1970 Aug;27(2):149–158. doi: 10.1161/01.res.27.2.149. [DOI] [PubMed] [Google Scholar]
  15. Patrick T. A., Vatner S. F., Kemper W. S., Franklin D. Telemetry of left ventricular diameter and pressure measurements from unrestrained animals. J Appl Physiol. 1974 Aug;37(2):276–281. doi: 10.1152/jappl.1974.37.2.276. [DOI] [PubMed] [Google Scholar]
  16. Schwartz P. J., Stone H. L. Tonic influence of the sympathetic nervous system on myocardial reactive hyperemia and on coronary blood flow distribution in dogs. Circ Res. 1977 Jul;41(1):51–58. doi: 10.1161/01.res.41.1.51. [DOI] [PubMed] [Google Scholar]
  17. Vatner S. F., Franklin D., Van Citters R. L., Braunwald E. Effects of carotid sinus nerve stimulation on the coronary circulation of the conscious dog. Circ Res. 1970 Jul;27(1):11–21. doi: 10.1161/01.res.27.1.11. [DOI] [PubMed] [Google Scholar]
  18. Vatner S. F., Higgins C. B., Braunwald E. Effects of norepinephrine on coronary circulation and left ventricular dynamics in the conscious dog. Circ Res. 1974 Jun;34(6):812–823. doi: 10.1161/01.res.34.6.812. [DOI] [PubMed] [Google Scholar]
  19. Vatner S. F., McRitchie R. J. Interaction of the chemoreflex and the pulmonary inflation reflex in the regulation of coronary circulation in conscious dogs. Circ Res. 1975 Nov;37(5):664–673. doi: 10.1161/01.res.37.5.664. [DOI] [PubMed] [Google Scholar]
  20. Winbury M. M., Howe B. B., Hefner M. A. Effect of nitrates and other coronary dilators on large and small coronary vessels: an hypothesis for the mechanism of action of nitrates. J Pharmacol Exp Ther. 1969 Jul;168(1):70–95. [PubMed] [Google Scholar]

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