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. Author manuscript; available in PMC: 2014 Jun 24.
Published in final edited form as: Tetrahedron. 2013 Apr 15;69(25):5205–5220. doi: 10.1016/j.tet.2013.04.041

Scheme 3.

Scheme 3

Reductive coupling to access 18 and cyclization studies. Reagents and conditions: a) Ni(cod)2, Cyp3P, tBuMe2SiH, THF, rt, 67%, 1:1 dr; b) TBAF, THF, rt.