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. 1980 Jun;65(6):1491–1497. doi: 10.1172/JCI109814

Interaction of Cardiopulmonary and Somatic Reflexes in Humans

John L Walker 1,2, Francois M Abboud 1,2, Allyn L Mark 1,2, Marc D Thames 1,2
PMCID: PMC371488  PMID: 7410553

Abstract

Activation of cardiopulmonary receptors with vagal afferents results predominantly in reflex inhibition of efferent sympathetic activity, whereas activation of somatic receptors reflexly increases sympathetic activity to the heart and circulation. Previous studies in experimental animals indicate that there is an important interaction between these excitatory and inhibitory reflexes in the control of the renal circulation.

The purpose of this study was to determine whether there is a similar interaction between somatic and cardiopulmonary reflexes in humans. The activity of the cardiopulmonary receptors was altered (reduced) with lower body negative pressure (−5 mm Hg), which causes a decrease in cardiac filling pressure and a small reflex increase in forearm vascular resistance without accompanying changes in arterial pressure. Activation of somatic receptors by isometric handgrip for 2 min at 10 and 20% of maximum voluntary contraction resulted in reflex vasoconstriction in the nonexercising arm. Lower body negative pressure at −5 mm Hg produced a threefold augmentation in the forearm vasoconstrictor response to isometric handgrip in the nonexercising arm. This increase in resistance was significantly greater (P < 0.05) than the algebraic sum of the increases in resistance resulting from lower body suction alone plus isometric handgrip alone. Furthermore, it occurred despite a greater rise in arterial pressure, which would be expected to decrease forearm vascular resistance through activation of arterial baroreceptors and through passive dilatation of forearm vessels. Thus, removal of the inhibitory influence of cardiopulmonary receptors by pooling blood in the lower extremities enhances the somatic reflex. These data suggest an interaction between cardiopulmonary and somatic reflexes in the control of forearm vascular resistance in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrews C. J., Andrews W. H., Orbach J. A sympathetic reflex elicited by distension of the mesenteric venous bed. J Physiol. 1972 Oct;226(1):119–131. doi: 10.1113/jphysiol.1972.sp009976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bevegård B. S., Shepherd J. T. Reaction in man of resistance and capacity vessels in forearm and hand to leg exercise. J Appl Physiol. 1966 Jan;21(1):123–132. doi: 10.1152/jappl.1966.21.1.123. [DOI] [PubMed] [Google Scholar]
  3. Clement D. L., Pelletier C. L., Shepherd J. T. Role of vagal afferents in the control of renal sympathetic nerve activity in the rabbit. Circ Res. 1972 Dec;31(6):824–830. doi: 10.1161/01.res.31.6.824. [DOI] [PubMed] [Google Scholar]
  4. Fox I. J., Gerasch D. A., Leonard J. J. Left ventricular mechanoreceptors: a haemodynamic study. J Physiol. 1977 Dec;273(2):405–425. doi: 10.1113/jphysiol.1977.sp012101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Greenberg T. T., Richmond W. H., Stocking R. A., Gupta P. D., Meehan J. P., Henry J. P. Impaired atrial receptor responses in dogs with heart failure due to tricuspid insufficiency and pulmonary artery stenosis. Circ Res. 1973 Apr;32(4):424–433. doi: 10.1161/01.res.32.4.424. [DOI] [PubMed] [Google Scholar]
  6. Higgins C. B., Vatner S. F., Franklin D., Braunwald E. Effects of experimentally produced heart failure on the peripheral vascular response to severe exercise in conscious dogs. Circ Res. 1972 Aug;31(2):186–194. doi: 10.1161/01.res.31.2.186. [DOI] [PubMed] [Google Scholar]
  7. Johnson J. M., Rowell L. B., Niederberger M., Eisman M. M. Human splanchnic and forearm vasoconstrictor responses to reductions of right atrial and aortic pressures. Circ Res. 1974 Apr;34(4):515–524. doi: 10.1161/01.res.34.4.515. [DOI] [PubMed] [Google Scholar]
  8. Kivowitz C., Parmley W. W., Donoso R., Marcus H., Ganz W., Swan H. J. Effects of isometric exercise on cardiac performance. The grip test. Circulation. 1971 Dec;44(6):994–1002. doi: 10.1161/01.cir.44.6.994. [DOI] [PubMed] [Google Scholar]
  9. Koike H., Mark A. L., Heistad D. D., Schmid P. G. Influence of cardiopulmonary vagal afferent activity on carotid chemoreceptor and baroreceptor reflexes in the dog. Circ Res. 1975 Oct;37(4):422–429. doi: 10.1161/01.res.37.4.422. [DOI] [PubMed] [Google Scholar]
  10. Kumada M., Nogami K., Sagawa K. Modulation of carotid sinus baroreceptor reflex by sciatic nerve stimulation. Am J Physiol. 1975 May;228(5):1535–1541. doi: 10.1152/ajplegacy.1975.228.5.1535. [DOI] [PubMed] [Google Scholar]
  11. LIND A. R., TAYLOR S. H., HUMPHREYS P. W., KENNELLY B. M., DONALD K. W. THE CIRCULATIORY EFFECTS OF SUSTAINED VOLUNTARY MUSCLE CONTRACTION. Clin Sci. 1964 Oct;27:229–244. [PubMed] [Google Scholar]
  12. LITTER J., WILKINS R. W., WOOD J. E. Peripheral venoconstriction in human congestive heart failure. Circulation. 1956 Apr;13(4):524–527. doi: 10.1161/01.cir.13.4.524. [DOI] [PubMed] [Google Scholar]
  13. Mark A. L., Abboud F. M., Schmid P. G., Heistad D. D. Reflex vascular responses to left ventricular outflow obstruction and activation of ventricular baroreceptors in dogs. J Clin Invest. 1973 May;52(5):1147–1153. doi: 10.1172/JCI107281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McCloskey D. I., Mitchell J. H. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol. 1972 Jul;224(1):173–186. doi: 10.1113/jphysiol.1972.sp009887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Millard R. W., Higgins C. B., Franklin D., Vatner S. F. Regulation of the renal circulation during severe exercise in normal dogs and dogs with experimental heart failure. Circ Res. 1972 Dec;31(6):881–888. doi: 10.1161/01.res.31.6.881. [DOI] [PubMed] [Google Scholar]
  16. Oberg B., Thorén P. Circulatory responses to stimulation of left ventricular receptors in the cat. Acta Physiol Scand. 1973 May;88(1):8–22. doi: 10.1111/j.1748-1716.1973.tb05429.x. [DOI] [PubMed] [Google Scholar]
  17. Pickering T. G., Gribbin B., Petersen E. S., Cunningham D. J., Sleight P. Comparison of the effects of exercise and posture on the baroreflex in man. Cardiovasc Res. 1971 Oct;5(4):582–586. doi: 10.1093/cvr/5.4.582. [DOI] [PubMed] [Google Scholar]
  18. Pickering T. G., Gribbin B., Petersen E. S., Cunningham D. J., Sleight P. Effects of autonomic blockade on the baroreflex in man at rest and during exercise. Circ Res. 1972 Feb;30(2):177–185. doi: 10.1161/01.res.30.2.177. [DOI] [PubMed] [Google Scholar]
  19. Thames M. D., Abboud F. M. Interaction of somatic and cardiopulmonary receptors in control of renal circulation. Am J Physiol. 1979 Nov;237(5):H560–H565. doi: 10.1152/ajpheart.1979.237.5.H560. [DOI] [PubMed] [Google Scholar]
  20. Tibes U. Reflex inputs to the cardiovascular and respiratory centers from dynamically working canine muscles. Some evidence for involvement of group III or IV nerve fibers. Circ Res. 1977 Sep;41(3):332–341. doi: 10.1161/01.res.41.3.332. [DOI] [PubMed] [Google Scholar]
  21. WHITNEY R. J. The measurement of volume changes in human limbs. J Physiol. 1953 Jul;121(1):1–27. doi: 10.1113/jphysiol.1953.sp004926. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. WOOD J. E. The mechanism of the increased venous pressure with exercise in congestive heart failure. J Clin Invest. 1962 Nov;41:2020–2024. doi: 10.1172/JCI104660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Zoller R. P., Mark A. L., Abboud F. M., Schmid P. G., Heistad D. D. The role of low pressure baroreceptors in reflex vasoconstrictor responses in man. J Clin Invest. 1972 Nov;51(11):2967–2972. doi: 10.1172/JCI107121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Zucker I. H., Earle A. M., Gilmore J. P. The mechanism of adaptation of left atrial stretch receptors in dogs with chronic congestive heart failure. J Clin Invest. 1977 Aug;60(2):323–331. doi: 10.1172/JCI108780. [DOI] [PMC free article] [PubMed] [Google Scholar]

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