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. 1981 Jan;67(1):42–50. doi: 10.1172/JCI110031

Antihelper T cell autoantibody in acquired agammaglobulinemia.

A Rubinstein, M Sicklick, V Mehra, F S Rosen, R H Levey
PMCID: PMC371570  PMID: 6450224

Abstract

A patient with acquired agammaglobulinemia had an antihelper T cell factor that was identified as an immunoglobulin of the IgG class. The factor specifically bound to the TH2- T cell subset and, in the presence of complement, abolished the helper effect of normal T cells. The antihelper T cell antibody preceded by several years the appearance of suppressor TH2+Ia+ T cells, at which time the clinical course rapidly deteriorated. Plasmapheresis resulted in lymphocytosis and reappearance of a functionally intact helper T cell population. It did not affect the suppressor cells. Conversely, total thymectomy resulted in a temporary disappearance of the TH2+Ia+ suppressor cells, but did not decrease the levels of the autoantibody to helper T cells. Neither of these treatments reversed the state of agammaglobulinemia.

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Selected References

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