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. 1981 Jan;67(1):308–311. doi: 10.1172/JCI110028

Expansion of Fc receptor-bearing T lymphocytes in patients with immunoglobulin G and immunoglobulin A myeloma.

R G Hoover, S Hickman, H M Gebel, N Rebbe, R G Lynch
PMCID: PMC371601  PMID: 6969732

Abstract

Lymphocytes obtained from the blood of normal individuals and six patients with newly diagnosed multiple myeloma were separated into T and non-T cell populations by rosette-formation with sheep erythrocytes, and were then assayed for the presence of surface membrane Fc receptors. When compared with normal individuals, four patients with IgG myeloma had a three- to fourfold increase in T cells with IgG receptors (T gamma cells) and two patients with IgA myeloma had a two- to threefold increase in T cells with IgA receptors (T alpha cells). Patients with IgG or IgA myeloma had normal numbers of non-T lymphocytes with surface receptors for IgG and IgA, respectively. The finding that human myeloma is accompanied by elevated numbers of T cells with Fc receptors for the heavy chain class of the myeloma protein: (1) may account for the apparent "monoclonal" lymphocyte population in patients with myeloma; (b) extends to humans similar observations made in mice with secretory plasmacytomas; and (c) is of interest because T cells with Fc receptors are immunoregulatory lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdou N. I., Abdou N. L. The monoclonal nature of lymphocytes in multiple myeloma. Effects of therapy. Ann Intern Med. 1975 Jul;83(1):42–45. doi: 10.7326/0003-4819-83-1-42. [DOI] [PubMed] [Google Scholar]
  2. Böyum A. Separation of leukocytes from blood and bone marrow. Introduction. Scand J Clin Lab Invest Suppl. 1968;97:7–7. [PubMed] [Google Scholar]
  3. Ferrarini M., Moretta L., Abrile R., Durante M. L. Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells. Eur J Immunol. 1975 Jan;5(1):70–72. doi: 10.1002/eji.1830050115. [DOI] [PubMed] [Google Scholar]
  4. Gebel H. M., Hoover R. G., Lynch R. G. Lymphocyte surface membrane immunoglobulin in myeloma. I. M315-bearing T lymphocytes in mice with MOPC-315. J Immunol. 1979 Sep;123(3):1110–1116. [PubMed] [Google Scholar]
  5. Hannestad K., Kao M. S., Eisen H. N. Cell-bound myeloma proteins on the surface of myeloma cells: potential targets for the immune system. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2295–2299. doi: 10.1073/pnas.69.8.2295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hoover R. G., Lynch R. G. Lymphocyte surface membrane immunoglobulin in myeloma. II. T cells with IgA-Fc receptors are markedly increased in mice with IgA plasmacytomas. J Immunol. 1980 Sep;125(3):1280–1288. [PubMed] [Google Scholar]
  7. Lindström F. D., Hardy W. R., Eberle B. J., Williams R. C., Jr Multiple myeloma and benign monoclonal gammopathy: differentiation by immunofluorescence of lymphocytes. Ann Intern Med. 1973 Jun;78(6):837–844. doi: 10.7326/0003-4819-78-6-837. [DOI] [PubMed] [Google Scholar]
  8. Lum L. G., Muchmore A. V., Keren D., Decker J., Koski I., Strober W., Blaese R. M. A receptor for IgA on human T lymphocytes. J Immunol. 1979 Jan;122(1):65–69. [PubMed] [Google Scholar]
  9. Lynch R. G., Rohrer J. W., Odermatt B., Gebel H. M., Autry J. R., Hoover R. G. Immunoregulation of murine myeloma cell growth and differentiation: a monoclonal model of B cell differentiation. Immunol Rev. 1979;48:45–80. doi: 10.1111/j.1600-065x.1979.tb00298.x. [DOI] [PubMed] [Google Scholar]
  10. Mellstedt H., Hammarström S., Holm G. Monoclonal lymphocyte population in human plasma cell myeloma. Clin Exp Immunol. 1974 Jul;17(3):371–384. [PMC free article] [PubMed] [Google Scholar]
  11. Moretta L., Ferrarini M., Cooper M. D. Characterization of human T-cell subpopulations as defined by specific receptors for immunoglobulins. Contemp Top Immunobiol. 1978;8:19–53. doi: 10.1007/978-1-4684-0922-2_2. [DOI] [PubMed] [Google Scholar]
  12. Seligmann M., Preud'Homme J. L., Brouet J. C. B and T cell markers in human proliferative blood diseases and primary immunodeficiencies, with special reference to membrane bound immunoglobulins. Transplant Rev. 1973;16:85–113. doi: 10.1111/j.1600-065x.1973.tb00118.x. [DOI] [PubMed] [Google Scholar]
  13. Spiegelberg H. L., O'Connor R. D., Simon R. A., Mathison D. A. Lymphocytes with immunoglobulin E Fc receptors in patients with atopic disorders. J Clin Invest. 1979 Sep;64(3):714–720. doi: 10.1172/JCI109514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Warner T. F., Krueger R. G. Circulating lymphocytes and the spread of myeloma. Review of the evidence. Lancet. 1978 Jun 3;1(8075):1174–1176. doi: 10.1016/s0140-6736(78)90966-2. [DOI] [PubMed] [Google Scholar]
  15. Yakulis V., Bhoopalam N., Schade S., Heller P. Surface immunoglobulins of circulating lymphocytes in mouse plasmacytoma. I. Characteristics of lymphocyte surface immunoglobulins. Blood. 1972 Apr;39(4):453–464. [PubMed] [Google Scholar]
  16. Yodoi J., Ishizaka K. Lymphocytes bearing Fc receptors for IgE. I. Presence of human and rat T lymphocytes with Fc epsilon receptors. J Immunol. 1979 Jun;122(6):2577–2583. [PubMed] [Google Scholar]
  17. Yodoi J., Ishizaka T., Ishizaka K. Lymphocytes bearing Fc receptors for IgE. II. Induction of Fcepsilon-receptor bearing rat lymphocytes by IgE. J Immunol. 1979 Jul;123(1):455–462. [PubMed] [Google Scholar]

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