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. 1980 Oct;66(4):843–846. doi: 10.1172/JCI109922

Lymphocyte adherence to myelinated tissue in multiple sclerosis.

P Dore-Duffy, V Goertz, B L Rothman
PMCID: PMC371659  PMID: 6968323

Abstract

A small subpopulation of human peripheral blood T lymphocytes has the capacity to adhere selectively to myelinated sections of human and nonhuman brain tissue. Adherence of lymphocytes from patients with multiple sclerosis is significantly greater than adherence of control lymphocytes. Monocytes inhibit binding in controls. This function appears to be lost by multiple sclerosis monocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackerman S. K., Douglas S. D. Purification of human monocytes on microexudate-coated surfaces. J Immunol. 1978 Apr;120(4):1372–1374. [PubMed] [Google Scholar]
  2. Boyum A. Separation of blood leucocytes, granulocytes and lymphocytes. Tissue Antigens. 1974;4(4):269–274. [PubMed] [Google Scholar]
  3. Dore-Duffy P., Zurier R. B., Donaldson J., Nystrom S. S., Viola M. V., Rothman B., Thompson H. G. Lymphocyte adherence in multiple sclerosis. Neurology. 1979 Feb;29(2):232–235. doi: 10.1212/wnl.29.2.232. [DOI] [PubMed] [Google Scholar]
  4. Dore-Duffy P., Zurier R. B. Lymphocyte adherence in multiple sclerosis: effect of aspirin. J Clin Invest. 1979 Jan;63(1):154–157. doi: 10.1172/JCI109271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. KAPLOW L. S. SIMPLIFIED MYELOPEROXIDASE STAIN USING BENZIDINE DIHYDROCHLORIDE. Blood. 1965 Aug;26:215–219. [PubMed] [Google Scholar]
  6. Kuttner B. J., Woodruff J. J. Selective adherence of lymphocytes to myelinated areas of rat brain. J Immunol. 1979 May;122(5):1666–1671. [PubMed] [Google Scholar]
  7. Levy N. L., Auerbach P. S., Hayes E. C. A blood test for multiple sclerosis based on the adherence of lymphocytes to measles-infected cells. N Engl J Med. 1976 Jun 24;294(26):1423–1427. doi: 10.1056/NEJM197606242942604. [DOI] [PubMed] [Google Scholar]
  8. SCHUMACHER G. A., BEEBE G., KIBLER R. F., KURLAND L. T., KURTZKE J. F., MCDOWELL F., NAGLER B., SIBLEY W. A., TOURTELLOTTE W. W., WILLMON T. L. PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS. Ann N Y Acad Sci. 1965 Mar 31;122:552–568. doi: 10.1111/j.1749-6632.1965.tb20235.x. [DOI] [PubMed] [Google Scholar]
  9. Santoli D., Moretta L., Lisak R., Gilden D., Koprowski H. Imbalances in T cell subpopulations in multiple sclerosis patients. J Immunol. 1978 Apr;120(4):1369–1371. [PubMed] [Google Scholar]
  10. Woodruff J. J., Rasmussen R. A. In vitro adherence of lymphocytes to unfixed and fixed high endothelial cells of lymph nodes. J Immunol. 1979 Nov;123(5):2369–2372. [PubMed] [Google Scholar]
  11. Wybran J., Carr M. C., Fudenberg H. H. The human rosette-forming cell as a marker of a population of thymus-derived cells. J Clin Invest. 1972 Oct;51(10):2537–2543. doi: 10.1172/JCI107069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Zurier R. B., Dore-Duffy P., Viola M. V. Adherence of human peripheral blood lymphycytes to measles-infected cells. Enhancement by prostaglandin E1. N Engl J Med. 1977 Jun 23;296(25):1443–1446. doi: 10.1056/NEJM197706232962506. [DOI] [PubMed] [Google Scholar]

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