Abstract
Objective
A morphological analysis of the bone structure of C2 in patients with rheumatoid arthritis in order to enhance the security of the stabilization procedures for this vertebra.
Methods
We retrospectively analyzed 20 CT scans of the cervical spine performed in patients with rheumatoid arthritis; the following parameters were measured: spinolaminar angle, thickness and length of C2 lamina.
Results
The mean values are: 5.92mm and 5.87mm for thickness of right and left laminae retrospectively, 27.75mm for right lamina length and 27.94mm for left lamina length, and 44.7º for spinolaminar angle.
Conclusion
The values obtained are consistent with studies in normal subjects published by other groups, with no apparent need for change in the screw placement technique. Level of Evidence IV, Case Series.
Keywords: Axis; Arthritis, rheumatoid/radiography; Arthritis, rheumatoid/surgery; Anatomy
INTRODUCTION
The cervical region is commonly affected in rheumatoid arthritis. The frequency of clinical and radiographic involvement is as high as 72.5%.1 The physiopathology of the disease includes synovitis of the apophyseal joints, ligamentous laxity, loss of articular cartilage and bone erosion.2 The three most common lesions are: atlanto-axial subluxation (C1-C2), subaxial dislocation (below C2) and the destruction of the atlanto-axial and atlanto-occipital joints, leading to settling of the skull on the odontoid.3 Although cervical involvement is frequent, only a small percentage of patients have surgical indication. The indications for arthrodesis are: pain, instability and neurological deficit.4
Various techniques are used for stabilization of the upper cervical spine with laminar screws.5-7 Previous anatomical and8,9 tomographic studies10 evaluated the bone morphology of C2 in normal individuals with the objective of optimizing the safety of these methods. Other studies investigated the morphologic alterations of this region in patients with rheumatoid arthritis, but none of them focused on characterizing laminar alterations of C2 that would jeopardize surgical procedures at this site.1-4 This study addresses measurements of the bone structure of C2 in tomography scans of patients with rheumatoid arthritis.
MATERIALS AND METHODS
We retrospectively analyzed 20 tomography scans of patients with rheumatoid arthritis acquired for diagnosis and surgical planning. The dimensions and angulations of the laminae were evaluated using the ImageJ® imaging program.
The lamina thickness was measured in millimeters. In the axial section of C2 where the greatest laminar thickness was noted, the measurement was taken at the point of least thickness of each lamina in the chosen section. The thickness of the trabecular tissue was measured in the intercortical space. (Figure 1) Each measurement was taken specifically for each side of the lamina. The length of the laminae was measured in the same axial section. The measurement was taken from the cortex opposite the lamina up to the limit of the length visible in that section. (Figure 2) The spinolaminar angle was traced for both sides, with one of the lines inside the C2 lamina parallel to the cortexes of this lamina, and another line passing longitudinally through the spinous process of this vertebra. (Figure 3)
Figure 1.
Measurement of the thickness of the laminae
Figure 2.
Measurement of the length of the laminae
Figure 3.
Measurement of the right (A) and left (B) spinolaminar angle of the vertebra
RESULTS
Of the 20 tomography scans included in the study, 17 belonged to female patients and three to male patients. The average age of the patients from the study was 59 years for men and 60.4 years for women. The mean found for the spinolaminar angle was 44.70º (CI 95% 41.77º - 47.64º), while other means and their standard deviations are illustrated in Table 1.
Table 1.
Means and standard deviations obtained for total lamina thickness, trabecular tissue thickness and lamina length
| Lamina thickness | Trabecular tissue thickness | Lamina length | |
| Right | 5.92 mm (± 1.15) | 3.29 mm (± 1.13) | 27.75 mm (± 6.66) |
| Left | 5.87 mm (± 1.01) | 3.18 mm (± 1.10) | 27.94 mm (± 6.51) |
The comparative analysis between right and left sides for total lamina thickness, trabecular tissue thickness and lamina length, did not reveal any difference between the sides (p = 0.852, 0.715, 0.731 respectively). Table 2 contains the maximum and minimum limits of laminar thickness and length. Table 3 presents the values of the same parameters in healthy individuals obtained in a previous study.10
Table 2.
Maximum and minimum values of thickness and length obtained
| Laminar thickness | Laminar length | |
| Maximum value | 8.4 mm | 34.6 mm |
| Minimum value | 3.7 mm | 26.6 mm |
Table 3.
Comparison between the means of thickness, length and spinolaminar angle obtained in healthy patients and patients with rheumatoid arthritis
| Lamina thickness | Lamina length | Spinolaminar angle | |
| Rheumatoid Arthritis | 5.89 mm | 27.84 mm | 44.7º |
| Healthy individuals | 5.99 mm | 29.60 mm | 46.8º |
DISCUSSION
In the current literature we found various studies that use imaging methods to characterize the degenerations of the atlanto-axial joint of patients with rheumatoid arthritis.1-3,11,12 However, these studies are focused on the degenerative alterations of the joint and the development of instability. We do not find any study indicating the need for special precautions did the passage of intralaminar screws in patients with rheumatoid arthritis, such as passage of screws of reduced diameter or length due to deformities in the medullary canal of the C2 laminae.
It is a small study, with 20 cases, and only three male patients. Due to the disproportion between the sexes, it was not possible to conduct a comparative analysis between men and women. In the non-statistical comparison, with the results found in healthy individuals for the same parameters, published in a previous study by our group,10 we realized that the values obtained are equivalent, suggesting that in spite of the multiple joint alterations that develop with the pathology, there is no significant alteration of the morphology of the C2 vertebra.
The results of this study aim to corroborate the idea that the atlanto-axial stabilization procedures currently considered safe for healthy patients, are also safe for patients with rheumatoid arthritis, besides demonstrating that the passage of C2 intralaminar screws is safe, in observing that the minimum sizes found are larger than most of the screws used in this region (minimum thickness 3.7mm, minimum length 26.6mm).
CONCLUSION
The results obtained in the morphological analyses of C2 in patients with rheumatoid arthritis are similar to those of healthy patients, suggesting that there is no need to alter the placement technique of C2 intralaminar screws in patients with rheumatoid arthritis.
Footnotes
All the authors declare that there is no potential conflict of interest referring to this article.
Study conducted at LIM 41 – Laboratory of Medical Investigation of the Musculoskeletal System of the Department of Orthopedics and Traumatology of the School of Medicine of Universidade de São Paulo.
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