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. 1979 Jan;63(1):147–150. doi: 10.1172/JCI109269

C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation.

T W Muhlfelder, J Niemetz, D Kreutzer, D Beebe, P A Ward, S I Rosenfeld
PMCID: PMC371929  PMID: 762243

Abstract

Complement-activated human plasma causes generation of tissue factor in human leukocytes. This phenomenon appears to be related to the fifth component of complement (C5) as demonstrated by the use of C5 deficient-plasma and suppression of activity with antibody to C5. Isolation of the chemotactic factor from activated serum or trypsinization of purified C5 reproduces the phenomenon. These data provide evidence for a direct link between complement products and activation of the coagulation system. Because chemotactic peptides from C5 can be generated by a variety of enzymes, our findings suggest a relationship between complement, coagulation, and inflammation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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