Abstract
Plasma 1,25-dihydroxyvitamin D levels are elevated in early pregnancy and continue to increase throughout pregnancy. They remain elevated postpartum in lactating women. The elevated levels probably represent a physiological response to increased calcium requirements.
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- Boass A., Toverud S. U., McCain T. A., Pike J. W., Haussler M. R. Elevated serum levels of 1alpha, 25-dihydroxycholecalciferol in lactating rats. Nature. 1977 Jun 16;267(5612):630–632. doi: 10.1038/267630a0. [DOI] [PubMed] [Google Scholar]
- Cushard W. G., Jr, Creditor M. A., Canterbury J. M., Reiss E. Physiologic hyperparathyroidism in pregnancy. J Clin Endocrinol Metab. 1972 May;34(5):767–771. doi: 10.1210/jcem-34-5-767. [DOI] [PubMed] [Google Scholar]
- DeLuca H. F., Schnoes H. K. Metabolism and mechanism of action of vitamin D. Annu Rev Biochem. 1976;45:631–666. doi: 10.1146/annurev.bi.45.070176.003215. [DOI] [PubMed] [Google Scholar]
- Eisman J. A., Hamstra A. J., Kream B. E., DeLuca H. F. A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma. Arch Biochem Biophys. 1976 Sep;176(1):235–243. doi: 10.1016/0003-9861(76)90161-2. [DOI] [PubMed] [Google Scholar]
- Garabedian M., Holick M. F., Deluca H. F., Boyle I. T. Control of 25-hydroxycholecalciferol metabolism by parathyroid glands. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1673–1676. doi: 10.1073/pnas.69.7.1673. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haddad J. G., Chyu K. J. Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J Clin Endocrinol Metab. 1971 Dec;33(6):992–995. doi: 10.1210/jcem-33-6-992. [DOI] [PubMed] [Google Scholar]
- Heaney R. P., Skillman T. G. Calcium metabolism in normal human pregnancy. J Clin Endocrinol Metab. 1971 Oct;33(4):661–670. doi: 10.1210/jcem-33-4-661. [DOI] [PubMed] [Google Scholar]
- Hughes M. R., Brumbaugh P. F., Hussler M. R., Wergedal J. E., Baylink D. J. Regulation of serum 1alpha,25-dihydroxyvitamin D3 by calcium and phosphate in the rat. Science. 1975 Nov 7;190(4214):578–580. doi: 10.1126/science.1188357. [DOI] [PubMed] [Google Scholar]
- Kenny A. D. Vitamin D metabolism: physiological regulation in egg-laying Japanese quail. Am J Physiol. 1976 Jun;230(6):1609–1615. doi: 10.1152/ajplegacy.1976.230.6.1609. [DOI] [PubMed] [Google Scholar]
- Kumar R., Harnden D., DeLuca H. F. Metabolism of 1,25-dihydroxyvitamin D3: evidence for side-chain oxidation. Biochemistry. 1976 Jun 1;15(11):2420–2423. doi: 10.1021/bi00656a027. [DOI] [PubMed] [Google Scholar]
- Kumar R., Schnoes H. K., DeLuca H. F. Rat intestinal 25-hydroxyvitamin D3- and 1alpha,25-dihydroxyvitamin D3-24-hydroxylase. J Biol Chem. 1978 Jun 10;253(11):3804–3809. [PubMed] [Google Scholar]
- ROY E. J., MACKAY R. The concentration of oestrogens in blood during pregnancy. J Obstet Gynaecol Br Emp. 1962 Feb;69:13–17. doi: 10.1111/j.1471-0528.1962.tb00002.x. [DOI] [PubMed] [Google Scholar]
- Scriver C. R., Reade T. M., DeLuca H. F., Hamstra A. J. Serum 1,25-dihydroxyvitamin D levels in normal subjects and in patients with hereditary rickets or bone disease. N Engl J Med. 1978 Nov 2;299(18):976–979. doi: 10.1056/NEJM197811022991803. [DOI] [PubMed] [Google Scholar]
- Spanos E., Colston K. W., Evans I. M., Galante L. S., Macauley S. J., Macintyre I. Effect of prolactin on vitamin D metabolism. Mol Cell Endocrinol. 1976 Aug-Sep;5(3-4):163–167. doi: 10.1016/0303-7207(76)90080-0. [DOI] [PubMed] [Google Scholar]
- Turton C. W., Stanley P., Stamp T. C., Maxwell J. D. Altered vitamin-D metabolism in pregnancy. Lancet. 1977 Jan 29;1(8005):222–225. doi: 10.1016/s0140-6736(77)91017-0. [DOI] [PubMed] [Google Scholar]