Table 3.
Clinical variables by participant relationship to proband
| Summary of demographic data of probands and their relatives | Relationship to Proband | Control | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Proband | Full Sibling | Child | Parent | Cousin | Aunt/Uncle | Half Sibling | |||
| Total (N = 1097) | 322 | 335 | 81 | 20 | 20 | 9 | 6 | 304 | |
| Age | Mean | 68.8 | 66.5 | 48.8 | 79.0 | 67.5 | 67.9 | 63.2 | 70.3 |
| Median | 69.6 | 67.2 | 49.3 | 80.1 | 65.3 | 65.6 | 59.6 | 68.9 | |
| Std | 10.3 | 10.9 | 9.9 | 7.9 | 11.0 | 15.5 | 11.9 | 7.1 | |
| Min | 38.7 | 30.9 | 20.4 | 63.7 | 47.8 | 46.5 | 51.3 | 60.0 | |
| Max | 92.7 | 90.6 | 69.5 | 96.8 | 85.7 | 84.3 | 82.8 | 91.2 | |
| Worst FECD* Grade | Mean | 5.6 | 4.1 | 2.7 | 4.0 | 4.4 | 3.7 | 1.8 | 0 |
| Median | 6.0 | 5.0 | 3.0 | 5.0 | 5.0 | 4.0 | 0.0 | 0 | |
| Std | 0.6 | 1.8 | 2.0 | 2.0 | 2.0 | 2.3 | 2.9 | 0 | |
| Min | 4.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Max | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | 6.0 | 0 | |
| Sex (N = 1097) | Male | 101 | 114 | 18 | 6 | 3 | 3 | 2 | 131 |
| Female | 221 | 221 | 63 | 14 | 17 | 6 | 4 | 173 | |
| Race (N = 1097) | White/Caucasian | 316 | 329 | 80 | 20 | 20 | 9 | 6 | 294 |
| Black/African American | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | |
| American Indian/Alaskan Native | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 4 | |
| Native Hawaiian or Other Pacific Islander | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | |
| Other | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |
*
Fuchs’ Endothelial Corneal Dystrophy