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. 1979 Apr;63(4):759–764. doi: 10.1172/JCI109360

Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals.

P C Giclas, M H Ginsberg, N R Cooper
PMCID: PMC372012  PMID: 438335

Abstract

10 mg of monosodium urate crystals reduced the CH50 of 1 ml of human serum by 57% after 30 min at 37 degrees C. C1, C4, and C3 depletion of 52, 68, and 46% were typical of classical pathway activation. C1 binding and activation occurred when urate crystals were incubated with isolated precursor C1, and required the intact macromolecule, C1qrs. Activation of isolated C1 by urate crystals was not diminished by F(ab')2 anti-Fc under conditions in which C1 activation by aggregated immunoglobulin (G) was blocked by the F(ab')2 antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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