Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1979 Jul;64(1):1–7. doi: 10.1172/JCI109427

Mechanisms of Renin Secretion during Hemorrhage in the Dog

William L Henrich 1, Robert W Schrier 1, Tomas Berl 1, David Hyde 1, Marilyn Bard 1, Richard Rush 1, Abby Erickson 1
PMCID: PMC372084  PMID: 447846

Abstract

The importance of renal perfusion pressure (RPP), the sympathetic beta adrenergic nervous system and renal prostaglandins (PG) on renin release during a uniform 15-17% reduction in blood pressure by hemorrhage (HH) was studied systematically in anesthetized dogs. All groups of animals had similar decrements in systemic and renal hemodynamics with HH. In control dogs (n = 7), both plasma renin activity (PRA, 4.1-9.0 ng angiotensin I/ml per h, P < 0.05) and renin secretory rate (RSR, 26-228 ng/ml per h·min, P < 0.005) increased significantly with HH. This increase in renin release during HH was not abolished by any single maneuver alone including beta adrenergic blockade with d,l-propranolol (n = 6), renal PG inhibition with indomethacin (n = 7), or control of RPP (n = 6). However, when beta adrenergic blockade was combined with control of RPP (n = 7) during HH, neither PRA (1.9-2.7 ng/ml per h, NS) nor RSR (16-53 ng/ml per h·min, NS) increased significantly. Similarly, a combination of beta adrenergic blockade and PG inhibition (n = 6) also abolished the increase in PRA (1.5-1.4 ng/ml per h, NS) and RSR (14-55 ng/ml per h·min, NS) during HH despite significant decreases in sodium excretion. Finally, a combination of PG inhibition and RPP control was associated with significant increases in PRA and RSR during HH. These results support a multifactorial mechanism in renin release during HH and implicate both the beta adrenergic receptors, renal baroreceptors, and possibly the macula densa as constituting the primary pathways of renin release during HH of this magnitude. Because either constant RPP or PG inhibition blunted renin release during HH in the setting of beta adrenergic blockade, the present results strongly suggest that the renal baroreceptor, and probably the macula densa mechanism are PG mediated.

Full text

PDF
1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson R. J., Taher M. S., Cronin R. E., McDonald K. M., Schrier R. W. Effect of beta-adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. Am J Physiol. 1975 Sep;229(3):731–736. doi: 10.1152/ajplegacy.1975.229.3.731. [DOI] [PubMed] [Google Scholar]
  2. Blaine E. H., Davis J. O. Evidence for a renal vascular mechanism in renin release: new observations with graded stimulation by aortic constriction. Circ Res. 1971 May;28(5 Suppl):118–126. doi: 10.1161/01.res.28.5.ii-118. [DOI] [PubMed] [Google Scholar]
  3. Blaine E. H., Davis J. O., Prewitt R. L. Evidence for a renal vascular receptor in control of renin secretion. Am J Physiol. 1971 Jun;220(6):1593–1597. doi: 10.1152/ajplegacy.1971.220.6.1593. [DOI] [PubMed] [Google Scholar]
  4. Brown J. J., Davies D. L., Lever A. F., Robertson J. I., Verniory A. The effect of acute haemorrhage in the dog and man on plasma-renin concentration. J Physiol. 1966 Feb;182(3):649–663. doi: 10.1113/jphysiol.1966.sp007842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bunag R. D., Page I. H., McCubbin J. W. Neural stimulation of release of renin. Circ Res. 1966 Oct;19(4):851–858. doi: 10.1161/01.res.19.4.851. [DOI] [PubMed] [Google Scholar]
  6. Data J. L., Gerber J. G., Crump W. J., Frölich J. C., Hollifield J. W., Nies A. S. The prostaglandin system. A role in canine baroreceptor control of renin release. Circ Res. 1978 Apr;42(4):454–458. doi: 10.1161/01.res.42.4.454. [DOI] [PubMed] [Google Scholar]
  7. Henrich W. L., Anderson R. J., Berns A. S., McDonald K. M., Paulsen P. J., Berl T., Schrier R. W. The role of renal nerves and prostaglandins in control of renal hemodynamics and plasma renin activity during hypotensive hemorrhage in the dog. J Clin Invest. 1978 Mar;61(3):744–750. doi: 10.1172/JCI108988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Henrich W. L., Berl T., McDonald K. M., Anderson R. J., Schrier R. W. Angiotensin II, renal nerves, and prostaglandins in renal hemodynamics during hemorrhage. Am J Physiol. 1978 Jul;235(1):F46–F51. doi: 10.1152/ajprenal.1978.235.1.F46. [DOI] [PubMed] [Google Scholar]
  9. Jakschik B. A., Marshall G. R., Kourik J. L., Needleman P. Profile of circulating vasoactive substances in hemorrhagic shock and their pharmacologic manipulation. J Clin Invest. 1974 Oct;54(4):842–852. doi: 10.1172/JCI107824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Reid I. A., Schrier R. W., Earley L. E. An effect of extrarenal beta adrenergic stimulation on the release of renin. J Clin Invest. 1972 Jul;51(7):1861–1869. doi: 10.1172/JCI106988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Romero J. C., Dunlap C. L., Strong C. G. The effect of indomethacin and other anti-inflammatory drugs on the renin-angiotensin system. J Clin Invest. 1976 Aug;58(2):282–288. doi: 10.1172/JCI108470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SCORNIK O. A., PALADINI A. C. ANGIOTENSIN BLOOD LEVELS IN HEMORRHAGIC HYPOTENSION AND OTHER RELATED CONDITIONS. Am J Physiol. 1964 Mar;206:553–556. doi: 10.1152/ajplegacy.1964.206.3.553. [DOI] [PubMed] [Google Scholar]
  13. SKINNER S. L., MCCUBBIN J. W., PAGE I. H. CONTROL OF RENIN SECRETION. Circ Res. 1964 Jul;15:64–76. doi: 10.1161/01.res.15.1.64. [DOI] [PubMed] [Google Scholar]
  14. Schrier R. W., Humphreys M. H., Ufferman R. C. Role of cardiac output and the autonomic nervous system in the antinatriuretic response to acute constriction of the thoracic superior vena cava. Circ Res. 1971 Nov;29(5):490–498. doi: 10.1161/01.res.29.5.490. [DOI] [PubMed] [Google Scholar]
  15. Stockigt J. R., Collins R. D., Biglieri E. G. Determination of plasma renin concentration by angiotensin I immunoassay. Diagnotic import of precise measurement of subnormal renin in hyperaldosteronism. Circ Res. 1971 May;28(5 Suppl):175–191. doi: 10.1161/01.res.28.5.ii-175. [DOI] [PubMed] [Google Scholar]
  16. Taher M. S., McLain L. G., McDonald K. M., Schrier R. W., Gilbert L. K., Aisenbrey G. A., McCool A. L. Effect of beta adrenergic blockade on renin response to renal nerve stimulation. J Clin Invest. 1976 Feb;57(2):459–465. doi: 10.1172/JCI108297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Terragno N. A., Terragno D. A., McGiff J. C. Contribution of prostaglandins to the renal circulation in conscious, anesthetized, and laparotomized dogs. Circ Res. 1977 Jun;40(6):590–595. doi: 10.1161/01.res.40.6.590. [DOI] [PubMed] [Google Scholar]
  18. Ueda H., Yasuda H., Takabatake Y., Iizuka M., Iizuka T. Observations on the mechanism of renin release by catecholamines. Circ Res. 1970 Oct;27(Suppl):195+–195+. [PubMed] [Google Scholar]
  19. VANDER A. J., MILLER R. CONTROL OF RENIN SECRETION IN THE ANESTHETIZED DOG. Am J Physiol. 1964 Sep;207:537–546. doi: 10.1152/ajplegacy.1964.207.3.537. [DOI] [PubMed] [Google Scholar]
  20. Vander A. J. Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs. Am J Physiol. 1965 Sep;209(3):659–662. doi: 10.1152/ajplegacy.1965.209.3.659. [DOI] [PubMed] [Google Scholar]
  21. Vatner S. F. Effects of hemorrhage on regional blood flow distribution in dogs and primates. J Clin Invest. 1974 Aug;54(2):225–235. doi: 10.1172/JCI107757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Witty R. T., Davis J. O., Johnson J. A., Prewitt R. L. Effects of papaverine and hemorrhage on renin secretion in the nonfiltering kidney. Am J Physiol. 1971 Dec;221(6):1666–1671. doi: 10.1152/ajplegacy.1971.221.6.1666. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES