Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1979 Aug;64(2):620–626. doi: 10.1172/JCI109502

Reflex Cardiovascular Depression during Unilateral Lung Hyperinflation in the Dog

Sharon S Cassidy 1, William L Eschenbacher 1, Robert L Johnson Jr 1
PMCID: PMC372159  PMID: 457873

Abstract

We have examined whether lung hyperinflation in the anesthetized dog reflexly depresses cardiac output, stroke volume, heart rate, and blood pressure and whether these changes persist for more than a minute. To eliminate any mechanical restriction to venous return and pulmonary blood flow during lung hyperinflation, a model was developed in which all pulmonary artery blood flow and all ventilation were directed to the right lung in dogs with widely open chest and the left lung was hyperinflated before and after left cervical vagotomy. Heart rate, stroke volume, and blood pressure decreased by 24, 20, and 27%, respectively, within 15 s of left lung inflation to 30 cm H2O. Heart rate increased to preinflation levels by 1 min, but stroke volume and blood pressure remained depressed during lung hyperinflation for at least 15 min. Upon deflation, stroke volume and blood pressure returned to control levels within 1 min. Division of the left vagosympathetic trunk at the neck interrupted all autonomic afferent and efferent nerves of the left lung, but left intact the right vagal sympathetic and parasympathetic afferent and efferent nerves of the heart. After left cervical vagotomy the transient fall in heart rate, stroke volume, and blood pressure during left lung hyperinflation was greatly reduced or eliminated. These results suggest that unilateral lung hyperinflation reflexly depresses heart rate and blood pressure, which are partially compensated with time, and reflexly depresses stroke volume, which persists uncompensated until the lung is deflated. These findings may explain the depressed cardiovascular function observed during regional lung overdistention especially when it occurs during positive pressure ventilation.

Full text

PDF
620

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adrian E. D. Afferent impulses in the vagus and their effect on respiration. J Physiol. 1933 Oct 6;79(3):332–358. doi: 10.1113/jphysiol.1933.sp003053. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COLERIDGE H. M., COLERIDGE J. C., KIDD C. ROLE OF THE PULMONARY ARTERIAL BARORECEPTORS IN THE EFFECTS PRODUCED BY CAPSAICIN IN THE DOG. J Physiol. 1964 Mar;170:272–285. doi: 10.1113/jphysiol.1964.sp007330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cassidy S. S., Robertson C. H., Jr, Pierce A. K., Johnson R. L., Jr Cardiovascular effects of positive end-expiratory pressure in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1978 May;44(5):743–750. doi: 10.1152/jappl.1978.44.5.743. [DOI] [PubMed] [Google Scholar]
  4. Coleridge H. M., Coleridge J. C. Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs. Respir Physiol. 1977 Apr;29(2):125–142. doi: 10.1016/0034-5687(77)90086-x. [DOI] [PubMed] [Google Scholar]
  5. Coleridge H. M., Coleridge J. C., Luck J. C. Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs. J Physiol. 1965 Jul;179(2):248–262. doi: 10.1113/jphysiol.1965.sp007660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Coleridge J. C., Coleridge H. M. Afferent C-fibers and cardiorespiratory chemoreflexes. Am Rev Respir Dis. 1977 Jun;115(6 Pt 2):251–260. doi: 10.1164/arrd.1977.115.S.251. [DOI] [PubMed] [Google Scholar]
  7. DAWES G. S., COMROE J. H., Jr Chemoreflexes from the heart and lungs. Physiol Rev. 1954 Apr;34(2):167–201. doi: 10.1152/physrev.1954.34.2.167. [DOI] [PubMed] [Google Scholar]
  8. De Burgh Daly M., Hazzledine J. L., Ungar A. The reflex effects of alterations in lung volume on systemic vascular resistance in the dog. J Physiol. 1967 Feb;188(3):331–351. doi: 10.1113/jphysiol.1967.sp008142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Glick G., Wechsler A. S., Epstein S. E. Reflex cardiovascular depression produced by stimulation of pulmonary stretch receptors in the dog. J Clin Invest. 1969 Mar;48(3):467–473. doi: 10.1172/JCI106004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ott N. T., Shepherd J. T. Vasodepressor reflex from lung inflation in the rabbit. Am J Physiol. 1971 Sep;221(3):889–895. doi: 10.1152/ajplegacy.1971.221.3.889. [DOI] [PubMed] [Google Scholar]
  11. Paintal A. S. Vagal sensory receptors and their reflex effects. Physiol Rev. 1973 Jan;53(1):159–227. doi: 10.1152/physrev.1973.53.1.159. [DOI] [PubMed] [Google Scholar]
  12. SALISBURY P. F., GALLETTI P. M., LEWIN R. J., RIEBEN P. A. Stretch reflexes from the dog's lung to the systemic circulation. Circ Res. 1959 Jan;7(1):62–67. doi: 10.1161/01.res.7.1.62. [DOI] [PubMed] [Google Scholar]
  13. Sampson S. R., Vidruk E. H. Properties of 'irritant' receptors in canine lung. Respir Physiol. 1975 Oct;25(1):9–22. doi: 10.1016/0034-5687(75)90047-x. [DOI] [PubMed] [Google Scholar]
  14. Scharf S. M., Caldini P., Ingram R. H., Jr Cardiovascular effects of increasing airway pressure in the dog. Am J Physiol. 1977 Jan;232(1):H35–H43. doi: 10.1152/ajpheart.1977.232.1.H35. [DOI] [PubMed] [Google Scholar]
  15. WHITTENBERGER J. L., McGREGOR M., BERGLUND E., BORST H. G. Influence of state of inflation of the lung on pulmonary vascular resistance. J Appl Physiol. 1960 Sep;15:878–882. doi: 10.1152/jappl.1960.15.5.878. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES