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. 1979 Aug;64(2):684–688. doi: 10.1172/JCI109509

Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery.

E A Neuwelt, K R Maravilla, E P Frenkel, S I Rapaport, S A Hill, P A Barnett
PMCID: PMC372166  PMID: 457877

Abstract

The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course, and localization of osmotic blood-brain barrier disruption.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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