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. 1979 Oct;64(4):1016–1023. doi: 10.1172/JCI109538

Effect of Intact Parathyroid Hormone on Hepatic Glucose Release in the Dog

Keith A Hruska 1,2, Joan Blondin 1,2, Raymond Bass 1,2, Julio Santiago 1,2, Lorraine Thomas 1,2, Paul Altsheler 1,2, Kevin Martin 1,2, Saulo Klahr 1,2
PMCID: PMC372211  PMID: 479365

Abstract

The liver has been shown to remove parathyroid hormone (PTH) from its arterial circulation by a mechanism that is selective for the intact form of the peptide (PTH 1-84). The present studies demonstrate that PTH has biologic effects on the liver in vivo. Bovine PTH 1-84 stimulated hepatic glucose release in dogs with indwelling hepatic vein catheters from basal values of 31±8 to 68±9 mg/min per kg after bolus injections of PTH. The effect on hepatic glucose release was apparent by 5 min and persisted for the 80 min of observation. The NH2-terminal PTH fragment (syn b-PTH 1-34) had no effect. Bovine PTH 1-84 administered in doses designed to produce circulating levels of immunoreactive PTH similar to the endogenous levels observed in uremic dogs also increased the incorporation of 14C from infused [14C]alanine into glucose, and increased estimated hepatic uptake of both chemical and [14C]alanine, while increasing hepatic glucose release. Thus, administration of “physiologic levels” of b-PTH 1-84 stimulated hepatic glucose release in part through increased gluconeogenesis in vivo, whereas syn b-PTH 1-34 had no demonstrable effect. Circulating levels of insulin rose after PTH administration, an increase which presumably represents a secondary response to the rise in glucose release.

These results suggest that the liver is a target organ of PTH, and that PTH might potentially alter carbohydrate metabolism during hypersecretion. They also suggest that hepatic uptake of PTH may be related in part to production of a specific biologic effect rather than just simple peptide degradation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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