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Dopamine (DA) and 3, 4-dihydroxyphenylacetic acid (DOPAC) time courses. (A) DOPAC/protein as measured by HPLC. Lights are turned on at ZT0 and turned off at ZT12. Dark phase is indicated by gray bar. Points plotted are mean +/− standard error of the mean (SEM). n = 5-7 animals per time point. (B) As A, but DA/protein as measured by HPLC. (C) As A, but DOPAC/DA as measured by HPLC. All measures are reported as picomoles of monoamine per milligram of protein.
