Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1977 Apr;59(4):609–615. doi: 10.1172/JCI108678

Studies of the mechanism of contralateral polyuria after renal artery stenosis.

O G Galvez, B W Roberts, M H Mishkind, W H Bay, T F Ferris
PMCID: PMC372264  PMID: 845253

Abstract

Acute renal artery stenosis in hydropenic dogs caused a contralateral increase in urine volume and free water clearance without change in glomerular filtration, renal blood flow, or osmolar clearance. The increase in urine volume was not dependent on the development of hypertension since it occurred in animals pretreated with trimethaphan but was dependent upon angiotensin since it was presented with angiotensin blockade with Saralasin. The effect was not caused by angiotensin inhibiting antidiuretic hormone release since the polyuria occurred in hypophysectomized animals receiving a constant infusion of 10 muU/kg per min of aqueous Pitressin. Since the rise in urine volume was associated with an increase in renal vein prostaglandin E concentration and was prevented by pretreatment with indomethacin (5 mg/kg) the results suggest that the rise in plasma angiotensin after renal artery stenosis causes an increase in contralateral prostaglandin E synthesis with resultant antagonism to antidiuretic hormone at the collecting tubule.

Full text

PDF
609

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aiken J. W. Effects of prostaglandin synthesis inhibitors on angiotensin tachyphylaxis in the isolated coeliac and mesenteric arteries of the rabbit. Pol J Pharmacol Pharm. 1974 Jan-Apr;26(1):217–227. [PubMed] [Google Scholar]
  2. Aiken J. W., Vane J. R. Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin. J Pharmacol Exp Ther. 1973 Mar;184(3):678–687. [PubMed] [Google Scholar]
  3. Anggård E., Bohman S. O., Griffin J. E., 3rd, Larsson C., Maunsbach A. B. Subcellular localization of the prostaglandin system in the rabbit renal papilla. Acta Physiol Scand. 1972 Feb;84(2):231–246. doi: 10.1111/j.1748-1716.1972.tb05174.x. [DOI] [PubMed] [Google Scholar]
  4. BALDWIN D. S., GOMBOS E. A., CHASIS H. Changes in sodium and water excretion induced by epinephrine and I-norepinephrine in normotensive and hypertensive subjects. J Lab Clin Med. 1963 May;61:832–857. [PubMed] [Google Scholar]
  5. BROWN J. J., DAVIES D. L., LEVER A. F., ROBERTSON J. I. PLASMA RENIN CONCENTRATION IN HUMAN HYPERTENSION. 1. RELATIONSHIP BETWEEN RENIN, SODIUM, AND POTASSIUM. Br Med J. 1965 Jul 17;2(5454):144–148. doi: 10.1136/bmj.2.5454.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Beck N. P., Reed S. W., Murdaugh H. V., Davis B. B. Effects of catecholamines and their interaction with other hormones on cyclic 3',5'-adenosine monophosphate of the kidney. J Clin Invest. 1972 Apr;51(4):939–944. doi: 10.1172/JCI106888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cadnapaphornchai P., Boykin J., Harbottle J. A., McDonald K. M., Schrier R. W. Effect of angiotensin II on renal water excretion. Am J Physiol. 1975 Jan;228(1):155–159. doi: 10.1152/ajplegacy.1975.228.1.155. [DOI] [PubMed] [Google Scholar]
  8. Claybaugh J. R., Share L., Shimizu K. The inability of infusions of angiotensin to elevate the plasma vasopressin in the anesthetized dog. Endocrinology. 1972 Jun;90(6):1647–1652. doi: 10.1210/endo-90-6-1647. [DOI] [PubMed] [Google Scholar]
  9. Domenech R. J., Hoffman J. I., Noble M. I., Saunders K. B., Henson J. R., Subijanto S. Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ Res. 1969 Nov;25(5):581–596. doi: 10.1161/01.res.25.5.581. [DOI] [PubMed] [Google Scholar]
  10. Fisher D. A. Norepinephrine inhibition of vasopressin antidiuresis. J Clin Invest. 1968 Mar;47(3):540–547. doi: 10.1172/JCI105750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gimbrone M. A., Jr, Alexander R. W. Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium. Science. 1975 Jul 18;189(4198):219–220. doi: 10.1126/science.1138377. [DOI] [PubMed] [Google Scholar]
  12. Grantham J. J., Orloff J. Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3',5'-monophosphate, and theophylline. J Clin Invest. 1968 May;47(5):1154–1161. doi: 10.1172/JCI105804. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HENRY J. P., GAUER O. H., REEVES J. L. Evidence of the atrial location of receptors influencing urine flow. Circ Res. 1956 Jan;4(1):85–90. doi: 10.1161/01.res.4.1.85. [DOI] [PubMed] [Google Scholar]
  14. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  15. Handler J. S., Bensinger R., Orloff J. Effect of adrenergic agents on toad bladder response to ADH, 3',5'-AMP, and theophylline. Am J Physiol. 1968 Nov;215(5):1024–1031. doi: 10.1152/ajplegacy.1968.215.5.1024. [DOI] [PubMed] [Google Scholar]
  16. Ishii M., Tobian L. Interstitial cell granules in renal papilla and the solute composition of renal tissue in rats with Goldblatt hypertension. J Lab Clin Med. 1969 Jul;74(1):47–52. [PubMed] [Google Scholar]
  17. Janszen F. H., Nugteren D. H. Histochemical localisation of prostaglandin synthetase. Histochemie. 1971;27(2):159–164. doi: 10.1007/BF00284957. [DOI] [PubMed] [Google Scholar]
  18. Kirschenbaum M. A., White N., Stein J. H., Ferris T. F. Redistribution of renal cortical blood flow during inhibition of prostaglandin synthesis. Am J Physiol. 1974 Oct;227(4):801–805. doi: 10.1152/ajplegacy.1974.227.4.801. [DOI] [PubMed] [Google Scholar]
  19. LEDSOME J. R., LINDEN R. J., O'CONNOR W. J. The mechanisms by which distension of the left atrium produces diuresis in anaesthetized dogs. J Physiol. 1961 Nov;159:87–100. doi: 10.1113/jphysiol.1961.sp006794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. LYDTIN H., HAMILTON W. F. EFFECT OF ACUTE CHANGES IN LEFT ATRIAL PRESSURE ON URINE FLOW IN UNANESTHETIZED DOGS. Am J Physiol. 1964 Sep;207:530–536. doi: 10.1152/ajplegacy.1964.207.3.530. [DOI] [PubMed] [Google Scholar]
  21. McGiff J. C., Crowshaw K., Terragno N. A., Lonigro A. J. Release of a prostaglandin-like substance into renal venous blood in response to angiotensin II. Circ Res. 1970 Jul;27(1 Suppl 1):121–130. [PubMed] [Google Scholar]
  22. McGiff J. C., Crowshaw K., Terragno N. A., Malik K. U., Lonigro A. J. Differential effect of noradrenaline and renal nerve stimulation on vascular resistance in the dog kidney and the release of a prostaglandin E-like substance. Clin Sci. 1972 Feb;42(2):223–233. doi: 10.1042/cs0420223. [DOI] [PubMed] [Google Scholar]
  23. Mouw D., Bonjour J. P., Malvin R. L., Vander A. Central action of angiotensin in stimulating ADH release. Am J Physiol. 1971 Jan;220(1):239–242. doi: 10.1152/ajplegacy.1971.220.1.239. [DOI] [PubMed] [Google Scholar]
  24. ORLOFF J., HANDLER J. S., BERGSTROM S. EFFECT OF PROSTAGLANDIN (PGE-1) ON THE PERMEABILITY RESPONSE OF TOAD BLADDER TO VASOPRESSIN, THEOPHYLLINE AND ADENOSINE 3',5'-MONOPHOSPHATE. Nature. 1965 Jan 23;205:397–398. doi: 10.1038/205397a0. [DOI] [PubMed] [Google Scholar]
  25. Orloff J., Handler J. The role of adenosine 3',5'-phosphate in the action of antidiuretic hormone. Am J Med. 1967 May;42(5):757–768. doi: 10.1016/0002-9343(67)90093-9. [DOI] [PubMed] [Google Scholar]
  26. PAPPER S., BELSKY J. L., BLEIFER K. H. The response to the administration of an isotonic sodium chloride-lactate solution in patients with essential hypertension. J Clin Invest. 1960 Jun;39:876–884. doi: 10.1172/JCI104108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Pugsley D. J., Beilin L. J., Peto R. Renal prostaglandin synthesis in the Goldblatt hypertensive rat. Circ Res. 1975 Jun;36(6 Suppl 1):81–88. doi: 10.1161/01.res.36.6.81. [DOI] [PubMed] [Google Scholar]
  28. Rector J. B., Stein J. H., Bay W. H., Osgood R. W., Ferris T. F. Effect of hemorrhage and vasopressor agents on distribution of renal blood flow. Am J Physiol. 1972 May;222(5):1125–1131. doi: 10.1152/ajplegacy.1972.222.5.1125. [DOI] [PubMed] [Google Scholar]
  29. Robertson G. L., Mahr E. A., Athar S., Sinha T. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. J Clin Invest. 1973 Sep;52(9):2340–2352. doi: 10.1172/JCI107423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. SELKURT E. E. Effect of pulse pressure and mean arterial pressure modification on renal hemodynamics and electrolyte and water excretion. Circulation. 1951 Oct;4(4):541–551. doi: 10.1161/01.cir.4.4.541. [DOI] [PubMed] [Google Scholar]
  31. SHARE L., LEVY M. N. Cardiovascular receptors and blood titer of antidiuretic hormone. Am J Physiol. 1962 Sep;203:425–428. doi: 10.1152/ajplegacy.1962.203.3.425. [DOI] [PubMed] [Google Scholar]
  32. SMYTHE C. M., NICKEL J. F., BRADLEY S. E. The effect of epinephrine (USP), l-epinephrine, and l-norepinephrine on glomerular filtration rate, renal plasma flow, and the urinary excretion of sodium, potassium, and water in normal man. J Clin Invest. 1952 May;31(5):499–506. doi: 10.1172/JCI102634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Schrier R. W., Berl T. Mechanism of effect of alpha adrenergic stimulation with norepinephrine on renal water excretion. J Clin Invest. 1973 Feb;52(2):502–511. doi: 10.1172/JCI107207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Schrier R. W., Berl T. Nonosmolar factors affecting renal water excretion (second of two parts). N Engl J Med. 1975 Jan 16;292(3):141–145. doi: 10.1056/NEJM197501162920306. [DOI] [PubMed] [Google Scholar]
  35. Schrier R. W., Lieberman R., Ufferman R. C. Mechanism of antidiuretic effect of beta adrenergic stimulation. J Clin Invest. 1972 Jan;51(1):97–111. doi: 10.1172/JCI106803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Stumpe K. O., Lowitz H. D., Ochwadt B. Fluid reabsorption in Henle's loop and urinary excretion of sodium and water in normal rats and rats with chronic hypertension. J Clin Invest. 1970 Jun;49(6):1200–1212. doi: 10.1172/JCI106334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Vane J. R., McGiff J. C. Possible contributions of endogenous prostaglandins to the control of blood pressure. Circ Res. 1975 Jun;36(6 Suppl 1):68–75. doi: 10.1161/01.res.36.6.68. [DOI] [PubMed] [Google Scholar]
  38. Venuto R. C., O'Dorisio T., Stein J. H., Ferris T. F. Uterine prostaglandin E secretion and uterine blood flow in the pregnant rabbit. J Clin Invest. 1975 Jan;55(1):193–197. doi: 10.1172/JCI107911. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES