Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1977 Dec;60(6):1438–1441. doi: 10.1172/JCI108905

The interrelationship between the release of renin and vasopressin as defined by orthostasis and propranolol.

R Davies, M L Forsling, J D Slater
PMCID: PMC372502  PMID: 915008

Abstract

The concentration of both plasma renin and plasma arginine vasopressin rose in normal subjects after an 85 degrees head-up tilt. Plasma renin activity, which increased 70-80% above the supine value, was maximal at 15 or 30 min, whereas the six- to seven-fold increase of plasma arginine vasopressin concentration was observed between 30 and 45 min. Intravenous propranolol administered just before tilt was used to investigate the possibility that the delayed rise of arginine vasopressin was stimulated by renin. Although the response of plasma renin was completely abolished by propranolol, the response of vasopressin was unaffected. These findings suggest that the release of vasopressin that follows isosmolar hypovolemia achieved by orthostasis may occur independently of changes in the renin-angiotensin system in the presence of propranolol.

Full text

PDF
1438

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson B., Eriksson L. Conjoint action of sodium and angiotensin on brain mechanisms controlling water and salt balances. Acta Physiol Scand. 1971 Jan;81(1):18–29. doi: 10.1111/j.1748-1716.1971.tb04873.x. [DOI] [PubMed] [Google Scholar]
  2. BROWN J. J., PEART W. S. The effect of angiotension on urine flow and electrolyte excretion in hypertensive patients. Clin Sci. 1962 Feb;22:1–17. [PubMed] [Google Scholar]
  3. Bunag R. D., Page I. H., McCubbin J. W. Inhibition of renin release by vasopressin and angiotensin. Cardiovasc Res. 1967 Jan;1(1):67–73. doi: 10.1093/cvr/1.1.67. [DOI] [PubMed] [Google Scholar]
  4. Claybaugh J. R., Share L., Shimizu K. The inability of infusions of angiotensin to elevate the plasma vasopressin in the anesthetized dog. Endocrinology. 1972 Jun;90(6):1647–1652. doi: 10.1210/endo-90-6-1647. [DOI] [PubMed] [Google Scholar]
  5. Davies R., Slater J. D., Forsling M. L., Payne N. The response of arginine vasopressin and plasma renin to postural change in normal man, with observations on syncope. Clin Sci Mol Med. 1976 Sep;51(3):267–274. doi: 10.1042/cs0510267. [DOI] [PubMed] [Google Scholar]
  6. Davies R., Slater J. D. Is the adrenergic control of renin release dominant in man? Lancet. 1976 Sep 18;2(7986):594–596. doi: 10.1016/s0140-6736(76)90665-6. [DOI] [PubMed] [Google Scholar]
  7. Düsterdieck G., McElwee G. Estimation of angiotensin II concentration in human plasma by radioimmunoassay. Some applications to physiological and clinical states. Eur J Clin Invest. 1971 Nov;2(1):32–38. doi: 10.1111/j.1365-2362.1971.tb00565.x. [DOI] [PubMed] [Google Scholar]
  8. Forsling M. L., Jones J. J., Lee J. Factors influencing the sensitivity of the rat to vasopressin. J Physiol. 1968 May;196(2):495–505. doi: 10.1113/jphysiol.1968.sp008520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GENEST J. Angiotensin, aldosterone and human arterial hypertension. Can Med Assoc J. 1961 Feb 25;84:403–419. [PMC free article] [PubMed] [Google Scholar]
  10. Hesse B., Nielsen I. Suppression of plasma renin activity by intravenous infusion of antidiuretic hormone in man. Clin Sci Mol Med. 1977 Apr;52(4):357–360. doi: 10.1042/cs0520357. [DOI] [PubMed] [Google Scholar]
  11. Khokhär A. M., Slater J. D., Forsling M. L., Payne N. N. Effect of vasopressin on plasma volume and renin release in man. Clin Sci Mol Med. 1976 May;50(5):415–424. doi: 10.1042/cs0500415. [DOI] [PubMed] [Google Scholar]
  12. Menard J., Catt K. J. Measurement of renin activity, concentration and substrate in rat plasma by radioimmunoassay of angiotensin I. Endocrinology. 1972 Feb;90(2):422–430. doi: 10.1210/endo-90-2-422. [DOI] [PubMed] [Google Scholar]
  13. Mouw D., Bonjour J. P., Malvin R. L., Vander A. Central action of angiotensin in stimulating ADH release. Am J Physiol. 1971 Jan;220(1):239–242. doi: 10.1152/ajplegacy.1971.220.1.239. [DOI] [PubMed] [Google Scholar]
  14. Nielsen I., Moller I. The relationship between plasma renin activity and hemoconcentration. Acta Med Scand. 1968 Apr;183(4):381–386. doi: 10.1111/j.0954-6820.1968.tb10495.x. [DOI] [PubMed] [Google Scholar]
  15. Share L., Claybaugh J. R., Hatch F. E., Jr, Johnson J. G., Lee S., Muirhead E. E., Shaw P. Effects of change in posture and of sodium depletion on plasma levels of vasopressin and renin in normal human subjects. J Clin Endocrinol Metab. 1972 Jul;35(1):171–174. doi: 10.1210/jcem-35-1-171. [DOI] [PubMed] [Google Scholar]
  16. Share L., Levy M. N. Carotid sinus pulse pressure, a determinant of plasma antidiuretic hormone concentration. Am J Physiol. 1966 Sep;211(3):721–724. doi: 10.1152/ajplegacy.1966.211.3.721. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES