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. 2012 Sep 28;1:22. doi: 10.1186/2193-1801-1-22

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© O’Shannessy et al.; licensee Springer. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FRA staining in normalbreast tissue and DCIS.a Normal breast tissue: strong 3+ membrane staining is seen on the luminal border of secretory cells. Myoepithelial cells in the outer layer of the duct are not stained (x40). b Ductal carcinoma in situ of breast, intermediate grade: the majority of tumor cells reveal 3+ strong or 2+ moderate membrane staining on the luminal and lateral cell borders (x20).