Table 3.

Average deformations (measured as the determinant of the Jacobian matrix at every voxel derived from the nonlinear registration deformation fields) are listed across the entire skull stripped brain when registering the FA images from each cohort’s subjects to the existing JHU template and the newly created ENIGMA–FA template. When comparing individuals from each site, there was a significant reduction in the amount of overall deformation required to warp the brains. Although the difference was not as pronounced, the significance and lower deformation level was also true for the UMCU data, which was not included in the creation of the template.

Average deformation	JHU template	ENIGMA–DTI template	Paired t-test
			p-Value
GOBS	0.3905	0.0555	<1 × 10−06
QTIM	0.3506	0.0374	<1 × 10−06
BFS	0.3581	0.0595	<1 × 10−06
LBC	0.0653	0.0026	<1 × 10−06
UMCU	0.3961	0.3178	<1 × 10−06