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. 1987 Jun;51(2):206–220. doi: 10.1128/mr.51.2.206-220.1987

Shiga and Shiga-like toxins.

A D O'Brien, R K Holmes
PMCID: PMC373104  PMID: 3299029

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRIDGWATER F. A., MORGAN R. S., ROWSON K. E., WRIGHT G. P. The neurotoxin of Shigella shigae: morphological and functional lesions produced in the central nervous system of rabbits. Br J Exp Pathol. 1955 Oct;36(5):447–453. [PMC free article] [PubMed] [Google Scholar]
  2. Baldini M. M., Kaper J. B., Levine M. M., Candy D. C., Moon H. W. Plasmid-mediated adhesion in enteropathogenic Escherichia coli. J Pediatr Gastroenterol Nutr. 1983;2(3):534–538. doi: 10.1097/00005176-198302030-00023. [DOI] [PubMed] [Google Scholar]
  3. Barksdale L., Arden S. B. Persisting bacteriophage infections, lysogeny, and phage conversions. Annu Rev Microbiol. 1974;28(0):265–299. doi: 10.1146/annurev.mi.28.100174.001405. [DOI] [PubMed] [Google Scholar]
  4. Beery J. T., Doyle M. P., Schoeni J. L. Colonization of chicken cecae by Escherichia coli associated with hemorrhagic colitis. Appl Environ Microbiol. 1985 Feb;49(2):310–315. doi: 10.1128/aem.49.2.310-315.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Betley M. J., Miller V. L., Mekalanos J. J. Genetics of bacterial enterotoxins. Annu Rev Microbiol. 1986;40:577–605. doi: 10.1146/annurev.mi.40.100186.003045. [DOI] [PubMed] [Google Scholar]
  6. Brown J. E., Griffin D. E., Rothman S. W., Doctor B. P. Purification and biological characterization of shiga toxin from Shigella dysenteriae 1. Infect Immun. 1982 Jun;36(3):996–1005. doi: 10.1128/iai.36.3.996-1005.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Brown J. E., Obrig T. G., Ussery M. A., Moran T. P. Shiga toxin from Shigella dysenteriae 1 inhibits protein synthesis in reticulocyte lysates by inactivation of aminoacyl-tRNA binding. Microb Pathog. 1986 Aug;1(4):325–334. doi: 10.1016/0882-4010(86)90065-3. [DOI] [PubMed] [Google Scholar]
  8. Brown J. E., Rothman S. W., Doctor B. P. Inhibition of protein synthesis in intact HeLa cells by Shigella dysenteriae 1 toxin. Infect Immun. 1980 Jul;29(1):98–107. doi: 10.1128/iai.29.1.98-107.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Brown J. E., Ussery M. A., Leppla S. H., Rothman S. W. Inhibition of protein synthesis by Shiga toxin: activation of the toxin and inhibition of peptide elongation. FEBS Lett. 1980 Aug 11;117(1):84–88. doi: 10.1016/0014-5793(80)80918-5. [DOI] [PubMed] [Google Scholar]
  10. Butler T., Speelman P., Kabir I., Banwell J. Colonic dysfunction during shigellosis. J Infect Dis. 1986 Nov;154(5):817–824. doi: 10.1093/infdis/154.5.817. [DOI] [PubMed] [Google Scholar]
  11. CAVANAGH J. B., HOWARD J. G., WHITBY J. L. The neurotoxin of Shigella shigae; a comparative study of the effects produced in various laboratory animals. Br J Exp Pathol. 1956 Jun;37(3):272–278. [PMC free article] [PubMed] [Google Scholar]
  12. Cantey J. R., Blake R. K. Diarrhea due to Escherichia coli in the rabbit: a novel mechanism. J Infect Dis. 1977 Mar;135(3):454–462. doi: 10.1093/infdis/135.3.454. [DOI] [PubMed] [Google Scholar]
  13. Cantey J. R. Shiga toxin--an expanding role in the pathogenesis of infectious diseases. J Infect Dis. 1985 May;151(5):766–771. doi: 10.1093/infdis/151.5.766. [DOI] [PubMed] [Google Scholar]
  14. Chen C., Kume T., Hohdatsu T., Tsubaki S. Escherichia coli originated from diarrhea of suckling piglets in Taiwan. III. Ability to produce enterotoxin and Vero cytotoxin. Kitasato Arch Exp Med. 1984 Sep;57(3):221–226. [PubMed] [Google Scholar]
  15. Clausen C. R., Christie D. L. Chronic diarrhea in infants caused by adherent enteropathogenic Escherichia coli. J Pediatr. 1982 Mar;100(3):358–361. doi: 10.1016/s0022-3476(82)80429-0. [DOI] [PubMed] [Google Scholar]
  16. Cleary T. G., Mathewson J. J., Faris E., Pickering L. K. Shiga-like cytotoxin production by enteropathogenic Escherichia coli serogroups. Infect Immun. 1985 Jan;47(1):335–337. doi: 10.1128/iai.47.1.335-337.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Donohue-Rolfe A., Kelley M. A., Bennish M., Keusch G. T. Enzyme-linked immunosorbent assay for shigella toxin. J Clin Microbiol. 1986 Jul;24(1):65–68. doi: 10.1128/jcm.24.1.65-68.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Donohue-Rolfe A., Keusch G. T., Edson C., Thorley-Lawson D., Jacewicz M. Pathogenesis of Shigella diarrhea. IX. Simplified high yield purification of Shigella toxin and characterization of subunit composition and function by the use of subunit-specific monoclonal and polyclonal antibodies. J Exp Med. 1984 Dec 1;160(6):1767–1781. doi: 10.1084/jem.160.6.1767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Donohue-Rolfe A., Keusch G. T. Shigella dysenteriae 1 cytotoxin: periplasmic protein releasable by polymyxin B and osmotic shock. Infect Immun. 1983 Jan;39(1):270–274. doi: 10.1128/iai.39.1.270-274.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Donowitz M., Keusch G. T., Binder H. J. Effect of Shigella enterotoxin on electrolyte transport in rabbit ileum. Gastroenterology. 1975 Dec;69(6):1230–1237. [PubMed] [Google Scholar]
  21. DuPont H. L., Hornick R. B., Dawkins A. T., Snyder M. J., Formal S. B. The response of man to virulent Shigella flexneri 2a. J Infect Dis. 1969 Mar;119(3):296–299. doi: 10.1093/infdis/119.3.296. [DOI] [PubMed] [Google Scholar]
  22. ENGLEY F. B., Jr The neurotoxin of Shigella dysenteriae (shiga). Bacteriol Rev. 1952 Sep;16(3):153–178. doi: 10.1128/br.16.3.153-178.1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Eidels L., Proia R. L., Hart D. A. Membrane receptors for bacterial toxins. Microbiol Rev. 1983 Dec;47(4):596–620. doi: 10.1128/mr.47.4.596-620.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Eiklid K., Olsnes S. Animal toxicity of Shigella dysenteriae cytotoxin: evidence that the neurotoxic, enterotoxic, and cytotoxic activities are due to one toxin. J Immunol. 1983 Jan;130(1):380–384. [PubMed] [Google Scholar]
  25. Eiklid K., Olsnes S. Entry of Shigella dysenteriae toxin into HeLa cells. Infect Immun. 1983 Nov;42(2):771–777. doi: 10.1128/iai.42.2.771-777.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Eiklid K., Olsnes S. Interaction of Shigella shigae cytotoxin with receptors on sensitive and insensitive cells. J Recept Res. 1980;1(2):199–213. doi: 10.3109/10799898009044098. [DOI] [PubMed] [Google Scholar]
  27. Francis D. H., Collins J. E., Duimstra J. R. Infection of gnotobiotic pigs with an Escherichia coli O157:H7 strain associated with an outbreak of hemorrhagic colitis. Infect Immun. 1986 Mar;51(3):953–956. doi: 10.1128/iai.51.3.953-956.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Fuchs G., Mobassaleh M., Donohue-Rolfe A., Montgomery R. K., Grand R. J., Keusch G. T. Pathogenesis of Shigella diarrhea: rabbit intestinal cell microvillus membrane binding site for Shigella toxin. Infect Immun. 1986 Aug;53(2):372–377. doi: 10.1128/iai.53.2.372-377.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. GASSER C., GAUTIER E., STECK A., SIEBENMANN R. E., OECHSLIN R. Hämolytisch-urämische Syndrome: bilaterale Nierenrindennekrosen bei akuten erworbenen hämolytischen Anämien. Schweiz Med Wochenschr. 1955 Sep 20;85(38-39):905–909. [PubMed] [Google Scholar]
  30. GIANANTONIO C., VITACCO M., MENDILAHARZU F., RUTTY A., MENDILAHARZU J. THE HEMOLYTIC-UREMIC SYNDROME. J Pediatr. 1964 Apr;64:478–491. doi: 10.1016/s0022-3476(64)80337-1. [DOI] [PubMed] [Google Scholar]
  31. Gemski P., Jr, Takeuchi A., Washington O., Formal S. B. Shigellosis due to Shigella dysenteriae. 1. Relative importance of mucosal invasion versus toxin production in pathogenesis. J Infect Dis. 1972 Nov;126(5):523–530. doi: 10.1093/infdis/126.5.523. [DOI] [PubMed] [Google Scholar]
  32. Gentry M. K., Dalrymple J. M. Quantitative microtiter cytotoxicity assay for Shigella toxin. J Clin Microbiol. 1980 Sep;12(3):361–366. doi: 10.1128/jcm.12.3.361-366.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Griffin D. E., Gemski P. Release of Shiga toxin from Shigella dysenteriae 1 by polymyxin B. Infect Immun. 1983 Apr;40(1):425–428. doi: 10.1128/iai.40.1.425-428.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Griffin D. E., Gentry M. K., Brown J. E. Isolation and characterization of monoclonal antibodies to Shiga toxin. Infect Immun. 1983 Jul;41(1):430–433. doi: 10.1128/iai.41.1.430-433.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Guth B. E., Pickett C. L., Twiddy E. M., Holmes R. K., Gomes T. A., Lima A. A., Guerrant R. L., Franco B. D., Trabulsi L. R. Production of type II heat-labile enterotoxin by Escherichia coli isolated from food and human feces. Infect Immun. 1986 Nov;54(2):587–589. doi: 10.1128/iai.54.2.587-589.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Guth B. E., Twiddy E. M., Trabulsi L. R., Holmes R. K. Variation in chemical properties and antigenic determinants among type II heat-labile enterotoxins of Escherichia coli. Infect Immun. 1986 Nov;54(2):529–536. doi: 10.1128/iai.54.2.529-536.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. HOWARD J. G. Observations on the intoxication produced in mice and rabbits by the neurotoxin of Shigella shigae. Br J Exp Pathol. 1955 Oct;36(5):439–446. [PMC free article] [PubMed] [Google Scholar]
  38. Huang A., de Grandis S., Friesen J., Karmali M., Petric M., Congi R., Brunton J. L. Cloning and expression of the genes specifying Shiga-like toxin production in Escherichia coli H19. J Bacteriol. 1986 May;166(2):375–379. doi: 10.1128/jb.166.2.375-379.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Jacewicz M., Clausen H., Nudelman E., Donohue-Rolfe A., Keusch G. T. Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide. J Exp Med. 1986 Jun 1;163(6):1391–1404. doi: 10.1084/jem.163.6.1391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Jacewicz M., Keusch G. T. Pathogenesis of Shigella diarrhea. VIII. Evidence for a translocation step in the cytotoxic action of Shiga toxin. J Infect Dis. 1983 Nov;148(5):844–854. doi: 10.1093/infdis/148.5.844. [DOI] [PubMed] [Google Scholar]
  41. Jackson M. P., Newland J. W., Holmes R. K., O'Brien A. D. Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coli. Microb Pathog. 1987 Feb;2(2):147–153. doi: 10.1016/0882-4010(87)90106-9. [DOI] [PubMed] [Google Scholar]
  42. Kaper J. B., Lockman H., Baldini M. M., Levine M. M. Recombinant nontoxinogenic Vibrio cholerae strains as attenuated cholera vaccine candidates. Nature. 1984 Apr 12;308(5960):655–658. doi: 10.1038/308655a0. [DOI] [PubMed] [Google Scholar]
  43. Karch H., Heesemann J., Laufs R., O'Brien A. D., Tacket C. O., Levine M. M. A plasmid of enterohemorrhagic Escherichia coli O157:H7 is required for expression of a new fimbrial antigen and for adhesion to epithelial cells. Infect Immun. 1987 Feb;55(2):455–461. doi: 10.1128/iai.55.2.455-461.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Karch H., Heesemann J., Laufs R. Phage-associated cytotoxin production by and enteroadhesiveness of enteropathogenic Escherichia coli isolated from infants with diarrhea in West Germany. J Infect Dis. 1987 Apr;155(4):707–715. doi: 10.1093/infdis/155.4.707. [DOI] [PubMed] [Google Scholar]
  45. Karmali M. A., Petric M., Lim C., Cheung R., Arbus G. S. Sensitive method for detecting low numbers of verotoxin-producing Escherichia coli in mixed cultures by use of colony sweeps and polymyxin extraction of verotoxin. J Clin Microbiol. 1985 Oct;22(4):614–619. doi: 10.1128/jcm.22.4.614-619.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Karmali M. A., Petric M., Lim C., Fleming P. C., Arbus G. S., Lior H. The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J Infect Dis. 1985 May;151(5):775–782. doi: 10.1093/infdis/151.5.775. [DOI] [PubMed] [Google Scholar]
  47. Kashiwazaki M., Ogawa T., Isayama Y., Akaike Y., Tamura K., Sakazaki R. Detection of Vero cytotoxic strains of Escherichia coli isolated from diseased animals. Natl Inst Anim Health Q (Tokyo) 1980 Fall;20(3):116–117. [PubMed] [Google Scholar]
  48. Kashiwazaki M., Ogawa T., Nakamura K., Isayama Y., Tamura K., Sakazaki R. Vero cytotoxin produced by Escherichia coli strains of animal origin. Natl Inst Anim Health Q (Tokyo) 1981 Summer;21(2):68–72. [PubMed] [Google Scholar]
  49. Keenan K. P., Sharpnack D. D., Collins H., Formal S. B., O'Brien A. D. Morphologic evaluation of the effects of Shiga toxin and E coli Shiga-like toxin on the rabbit intestine. Am J Pathol. 1986 Oct;125(1):69–80. [PMC free article] [PubMed] [Google Scholar]
  50. Keusch G. T., Donohue-Rolfe A., Jacewicz M. Shigella toxin and the pathogenesis of shigellosis. Ciba Found Symp. 1985;112:193–214. doi: 10.1002/9780470720936.ch11. [DOI] [PubMed] [Google Scholar]
  51. Keusch G. T., Donohue-Rolfe A., Jacewicz M. Shigella toxin(s): description and role in diarrhea and dysentery. Pharmacol Ther. 1981;15(3):403–438. doi: 10.1016/0163-7258(81)90052-8. [DOI] [PubMed] [Google Scholar]
  52. Keusch G. T., Grady G. F., Mata L. J., McIver J. The pathogenesis of Shigella diarrhea. I. Enterotoxin production by Shigella dysenteriae I. J Clin Invest. 1972 May;51(5):1212–1218. doi: 10.1172/JCI106915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Keusch G. T., Jacewicz M., Donohue-Rolfe A. Pathogenesis of shigella diarrhea: evidence for an N-linked glycoprotein shigella toxin receptor and receptor modulation by beta-galactosidase. J Infect Dis. 1986 Feb;153(2):238–248. doi: 10.1093/infdis/153.2.238. [DOI] [PubMed] [Google Scholar]
  54. Keusch G. T., Jacewicz M., Levine M. M., Hornick R. B., Kochwa S. Pathogenesis of shigella diarrhea. Serum anticytotoxin antibody response produced by toxigenic and nontoxigenic Shigella dysenteriae 1. J Clin Invest. 1976 Jan;57(1):194–202. doi: 10.1172/JCI108259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Keusch G. T., Jacewicz M. Pathogenesis of Shigella diarrhea. VII. Evidence for a cell membrane toxin receptor involving beta1 leads to 4-linked N-acetyl-D-glucosamine oligomers. J Exp Med. 1977 Aug 1;146(2):535–546. doi: 10.1084/jem.146.2.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Keusch G. T., Jacewicz M. Serum enterotoxin-neutralizing antibody in human shigellosis. Nat New Biol. 1973 Jan 3;241(105):31–32. doi: 10.1038/newbio241031a0. [DOI] [PubMed] [Google Scholar]
  57. Keusch G. T., Jacewicz M. The pathogenesis of Shigella diarrhea. VI. Toxin and antitoxin in Shigella flexneri and Shigella sonnei infections in humans. J Infect Dis. 1977 Apr;135(4):552–556. doi: 10.1093/infdis/135.4.552. [DOI] [PubMed] [Google Scholar]
  58. Kinsey M. D., Formal S. B., Dammin G. J., Giannella R. A. Fluid and electrolyte transport in rhesus monkeys challenged intracecally with Shigella flexneri 2a. Infect Immun. 1976 Aug;14(2):368–371. doi: 10.1128/iai.14.2.368-371.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Konowalchuk J., Dickie N., Stavric S., Speirs J. I. Comparative studies of five heat-labile toxic products of Escherichia coli. Infect Immun. 1978 Dec;22(3):644–648. doi: 10.1128/iai.22.3.644-648.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Konowalchuk J., Speirs J. I., Stavric S. Vero response to a cytotoxin of Escherichia coli. Infect Immun. 1977 Dec;18(3):775–779. doi: 10.1128/iai.18.3.775-779.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Koster F., Levin J., Walker L., Tung K. S., Gilman R. H., Rahaman M. M., Majid M. A., Islam S., Williams R. C., Jr Hemolytic-uremic syndrome after shigellosis. Relation to endotoxemia and circulating immune complexes. N Engl J Med. 1978 Apr 27;298(17):927–933. doi: 10.1056/NEJM197804272981702. [DOI] [PubMed] [Google Scholar]
  62. Levine M. M., DuPont H. L., Formal S. B., Hornick R. B., Takeuchi A., Gangarosa E. J., Snyder M. J., Libonati J. P. Pathogenesis of Shigella dysenteriae 1 (Shiga) dysentery. J Infect Dis. 1973 Mar;127(3):261–270. doi: 10.1093/infdis/127.3.261. [DOI] [PubMed] [Google Scholar]
  63. Levine M. M., Edelman R. Enteropathogenic Escherichia coli of classic serotypes associated with infant diarrhea: epidemiology and pathogenesis. Epidemiol Rev. 1984;6:31–51. doi: 10.1093/oxfordjournals.epirev.a036274. [DOI] [PubMed] [Google Scholar]
  64. Marques L. R., Moore M. A., Wells J. G., Wachsmuth I. K., O'Brien A. D. Production of Shiga-like toxin by Escherichia coli. J Infect Dis. 1986 Aug;154(2):338–341. doi: 10.1093/infdis/154.2.338. [DOI] [PubMed] [Google Scholar]
  65. McIver J., Grady G. F., Formal S. B. Immunization with Shigella dysenteriae type 1: evaluation of antitoxic immunity in prevention of experimental disease in rhesus monkeys (Macaca mulatta). J Infect Dis. 1977 Sep;136(3):416–421. doi: 10.1093/infdis/136.3.416. [DOI] [PubMed] [Google Scholar]
  66. Middlebrook J. L., Dorland R. B. Bacterial toxins: cellular mechanisms of action. Microbiol Rev. 1984 Sep;48(3):199–221. doi: 10.1128/mr.48.3.199-221.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Newland J. W., Strockbine N. A., Miller S. F., O'Brien A. D., Holmes R. K. Cloning of Shiga-like toxin structural genes from a toxin converting phage of Escherichia coli. Science. 1985 Oct 11;230(4722):179–181. doi: 10.1126/science.2994228. [DOI] [PubMed] [Google Scholar]
  68. O'Brien A. D., LaVeck G. D., Griffin D. E., Thompson M. R. Characterization of Shigella dysenteriae 1 (Shiga) toxin purified by anti-Shiga toxin affinity chromatography. Infect Immun. 1980 Oct;30(1):170–179. doi: 10.1128/iai.30.1.170-179.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. O'Brien A. D., LaVeck G. D. Purification and characterization of a Shigella dysenteriae 1-like toxin produced by Escherichia coli. Infect Immun. 1983 May;40(2):675–683. doi: 10.1128/iai.40.2.675-683.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. O'Brien A. D., LaVeck G. D., Thompson M. R., Formal S. B. Production of Shigella dysenteriae type 1-like cytotoxin by Escherichia coli. J Infect Dis. 1982 Dec;146(6):763–769. doi: 10.1093/infdis/146.6.763. [DOI] [PubMed] [Google Scholar]
  71. O'Brien A. D., Laveck G. D. Immunochemical and cytotoxic activities of Shigella dysenteriae 1 (shiga) and shiga-like toxins. Infect Immun. 1982 Mar;35(3):1151–1154. doi: 10.1128/iai.35.3.1151-1154.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. O'Brien A. D., Newland J. W., Miller S. F., Holmes R. K., Smith H. W., Formal S. B. Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea. Science. 1984 Nov 9;226(4675):694–696. doi: 10.1126/science.6387911. [DOI] [PubMed] [Google Scholar]
  73. O'Brien A. D., Thompson M. R., Gemski P., Doctor B. P., Formal S. B. Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin. Infect Immun. 1977 Mar;15(3):796–798. doi: 10.1128/iai.15.3.796-798.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Obrig T. G., Moran T. P., Colinas R. J. Ribonuclease activity associated with the 60S ribosome-inactivating proteins ricin A, phytolaccin and Shiga toxin. Biochem Biophys Res Commun. 1985 Jul 31;130(2):879–884. doi: 10.1016/0006-291x(85)90498-x. [DOI] [PubMed] [Google Scholar]
  75. Olsnes S., Eiklid K. Isolation and characterization of Shigella shigae cytotoxin. J Biol Chem. 1980 Jan 10;255(1):284–289. [PubMed] [Google Scholar]
  76. Olsnes S., Reisbig R., Eiklid K. Subunit structure of Shigella cytotoxin. J Biol Chem. 1981 Aug 25;256(16):8732–8738. [PubMed] [Google Scholar]
  77. Padhye V. V., Kittell F. B., Doyle M. P. Purification and physicochemical properties of a unique Vero cell cytotoxin from Escherichia coli O157:H7. Biochem Biophys Res Commun. 1986 Sep 14;139(2):424–430. doi: 10.1016/s0006-291x(86)80008-0. [DOI] [PubMed] [Google Scholar]
  78. Pai C. H., Gordon R., Sims H. V., Bryan L. E. Sporadic cases of hemorrhagic colitis associated with Escherichia coli O157:H7. Clinical, epidemiologic, and bacteriologic features. Ann Intern Med. 1984 Dec;101(6):738–742. doi: 10.7326/0003-4819-101-6-738. [DOI] [PubMed] [Google Scholar]
  79. Pai C. H., Kelly J. K., Meyers G. L. Experimental infection of infant rabbits with verotoxin-producing Escherichia coli. Infect Immun. 1986 Jan;51(1):16–23. doi: 10.1128/iai.51.1.16-23.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. Pickett C. L., Twiddy E. M., Belisle B. W., Holmes R. K. Cloning of genes that encode a new heat-labile enterotoxin of Escherichia coli. J Bacteriol. 1986 Feb;165(2):348–352. doi: 10.1128/jb.165.2.348-352.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Potter M. E., Kaufmann A. F., Thomason B. M., Blake P. A., Farmer J. J., 3rd Diarrhea due to Escherichia coli O157:H7 in the infant rabbit. J Infect Dis. 1985 Dec;152(6):1341–1343. doi: 10.1093/infdis/152.6.1341. [DOI] [PubMed] [Google Scholar]
  82. Prado D., Cleary T. G., Pickering L. K., Ericsson C. D., Bartlett A. V., 3rd, DuPont H. L., Johnson P. C. The relation between production of cytotoxin and clinical features in shigellosis. J Infect Dis. 1986 Jul;154(1):149–155. doi: 10.1093/infdis/154.1.149. [DOI] [PubMed] [Google Scholar]
  83. Raghupathy P., Date A., Shastry J. C., Sudarsanam A., Jadhav M. Haemolytic-uraemic syndrome complicating shigella dystentery in south Indian children. Br Med J. 1978 Jun 10;1(6126):1518–1521. doi: 10.1136/bmj.1.6126.1518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Reisbig R., Olsnes S., Eiklid K. The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit. J Biol Chem. 1981 Aug 25;256(16):8739–8744. [PubMed] [Google Scholar]
  85. Riley L. W., Remis R. S., Helgerson S. D., McGee H. B., Wells J. G., Davis B. R., Hebert R. J., Olcott E. S., Johnson L. M., Hargrett N. T. Hemorrhagic colitis associated with a rare Escherichia coli serotype. N Engl J Med. 1983 Mar 24;308(12):681–685. doi: 10.1056/NEJM198303243081203. [DOI] [PubMed] [Google Scholar]
  86. Rothbaum R., McAdams A. J., Giannella R., Partin J. C. A clinicopathologic study of enterocyte-adherent Escherichia coli: a cause of protracted diarrhea in infants. Gastroenterology. 1982 Aug;83(2):441–454. [PubMed] [Google Scholar]
  87. Rout W. R., Formal S. B., Giannella R. A., Dammin G. J. Pathophysiology of Shigella diarrhea in the rhesus monkey: intestinal transport, morphological, and bacteriological studies. Gastroenterology. 1975 Feb;68(2):270–278. [PubMed] [Google Scholar]
  88. Sansonetti P. J., Hale T. L., Dammin G. J., Kapfer C., Collins H. H., Jr, Formal S. B. Alterations in the pathogenicity of Escherichia coli K-12 after transfer of plasmid and chromosomal genes from Shigella flexneri. Infect Immun. 1983 Mar;39(3):1392–1402. doi: 10.1128/iai.39.3.1392-1402.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Sansonetti P. J., Kopecko D. J., Formal S. B. Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect Immun. 1982 Mar;35(3):852–860. doi: 10.1128/iai.35.3.852-860.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Sansonetti P. J., Kopecko D. J., Formal S. B. Shigella sonnei plasmids: evidence that a large plasmid is necessary for virulence. Infect Immun. 1981 Oct;34(1):75–83. doi: 10.1128/iai.34.1.75-83.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Sansonetti P. J., d'Hauteville H., Ecobichon C., Pourcel C. Molecular comparison of virulence plasmids in Shigella and enteroinvasive Escherichia coli. Ann Microbiol (Paris) 1983 May-Jun;134A(3):295–318. [PubMed] [Google Scholar]
  92. Seidah N. G., Donohue-Rolfe A., Lazure C., Auclair F., Keusch G. T., Chrétien M. Complete amino acid sequence of Shigella toxin B-chain. A novel polypeptide containing 69 amino acids and one disulfide bridge. J Biol Chem. 1986 Oct 25;261(30):13928–13931. [PubMed] [Google Scholar]
  93. Sherwood D., Snodgrass D. R., O'Brien A. D. Shiga-like toxin production from Escherichia coli associated with calf diarrhoea. Vet Rec. 1985 Feb 23;116(8):217–218. doi: 10.1136/vr.116.8.217. [DOI] [PubMed] [Google Scholar]
  94. Smith H. W., Green P., Parsell Z. Vero cell toxins in Escherichia coli and related bacteria: transfer by phage and conjugation and toxic action in laboratory animals, chickens and pigs. J Gen Microbiol. 1983 Oct;129(10):3121–3137. doi: 10.1099/00221287-129-10-3121. [DOI] [PubMed] [Google Scholar]
  95. Strockbine N. A., Marques L. R., Holmes R. K., O'Brien A. D. Characterization of monoclonal antibodies against Shiga-like toxin from Escherichia coli. Infect Immun. 1985 Dec;50(3):695–700. doi: 10.1128/iai.50.3.695-700.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Strockbine N. A., Marques L. R., Newland J. W., Smith H. W., Holmes R. K., O'Brien A. D. Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities. Infect Immun. 1986 Jul;53(1):135–140. doi: 10.1128/iai.53.1.135-140.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Thompson M. R., Steinberg M. S., Gemski P., Formal S. B., Doctor B. P. Inhibition of in vitro protein synthesis by Shigella dysenteriae 1 toxin. Biochem Biophys Res Commun. 1976 Aug 9;71(3):783–788. doi: 10.1016/0006-291x(76)90899-8. [DOI] [PubMed] [Google Scholar]
  98. VAN HEYNINGEN W. E., GLADSTONE G. P. The neurotoxin of Shigella shigae. I. Production, purification and properties of the toxin. Br J Exp Pathol. 1953 Apr;34(2):202–216. [PMC free article] [PubMed] [Google Scholar]
  99. VICARI G., OLITZKI A. L., OLITZKI Z. The action of the thermolabile toxin of Shigella dysenteriae on cells cultivated in vitro. Br J Exp Pathol. 1960 Apr;41:179–189. [PMC free article] [PubMed] [Google Scholar]
  100. Wiley R. G., Donohue-Rolfe A., Keusch G. T. Axonally transported Shigella cytotoxin is neuronotoxic. J Neuropathol Exp Neurol. 1985 Sep;44(5):496–506. doi: 10.1097/00005072-198509000-00005. [DOI] [PubMed] [Google Scholar]
  101. Yutsudo T., Honda T., Miwatani T., Takeda Y. Characterization of purified Shiga toxin from Shigella dysenteriae 1. Microbiol Immunol. 1986;30(11):1115–1127. doi: 10.1111/j.1348-0421.1986.tb03041.x. [DOI] [PubMed] [Google Scholar]

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