Skip to main content
NCBI home page
Microbiological Reviews logoLink to Microbiological Reviews
. 1988 Jun;52(2):296–303. doi: 10.1128/mr.52.2.296-303.1988

Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases.

M Kilian, J Mestecky, M W Russell
PMCID: PMC373140  PMID: 3045518

Full text

PDF
296

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. André C., Lambert R., Bazin H., Heremans J. F. Interference of oral immunization with the intestinal absorption of heterologous albumin. Eur J Immunol. 1974 Oct;4(10):701–704. doi: 10.1002/eji.1830041013. [DOI] [PubMed] [Google Scholar]
  2. Bloch K. J., Walker W. A. Effect of locally induced intestinal anaphylaxis on the uptake of a bystander antigen. J Allergy Clin Immunol. 1981 Apr;67(4):312–316. doi: 10.1016/0091-6749(81)90027-0. [DOI] [PubMed] [Google Scholar]
  3. Brandtzaeg P. Human secretory immunoglobulins. II. Salivary secretions from individuals with selectively excessive or defective synthesis of serum immunoglobulins. Clin Exp Immunol. 1971 Jan;8(1):69–85. [PMC free article] [PubMed] [Google Scholar]
  4. Brandtzaeg P. Role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scand J Immunol. 1985 Aug;22(2):111–146. doi: 10.1111/j.1365-3083.1985.tb01866.x. [DOI] [PubMed] [Google Scholar]
  5. Bronson R. A., Cooper G. W., Rosenfeld D. L., Gilbert J. V., Plaut A. G. The effect of an IgA1 protease on immunoglobulins bound to the sperm surface and sperm cervical mucus penetrating ability. Fertil Steril. 1987 Jun;47(6):985–991. doi: 10.1016/s0015-0282(16)59234-6. [DOI] [PubMed] [Google Scholar]
  6. Brown T. A., Russell M. W., Mestecky J. Elimination of intestinally absorbed antigen into the bile by IgA. J Immunol. 1984 Feb;132(2):780–782. [PubMed] [Google Scholar]
  7. Burritt M. F., Calvanico N. J., Mehta S., Tomasi T. B., Jr Activation of the classical complement pathway by Fc fragment of human IgA. J Immunol. 1977 Feb;118(2):723–725. [PubMed] [Google Scholar]
  8. Cunningham-Rundles C., Brandeis W. E., Good R. A., Day N. K. Milk precipitins, circulating immune complexes, and IgA deficiency. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3387–3389. doi: 10.1073/pnas.75.7.3387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Edebo L., Richardson N., Feinstein A. The effects of binding mouse IgA to dinitrophenylated Salmonella typhimurium on physicochemical properties and interaction with phagocytic cells. Int Arch Allergy Appl Immunol. 1985;78(4):353–357. doi: 10.1159/000233912. [DOI] [PubMed] [Google Scholar]
  10. Fanger M. W., Goldstine S. N., Shen L. Cytofluorographic analysis of receptors for IgA on human polymorphonuclear cells and monocytes and the correlation of receptor expression with phagocytosis. Mol Immunol. 1983 Sep;20(9):1019–1027. doi: 10.1016/0161-5890(83)90043-3. [DOI] [PubMed] [Google Scholar]
  11. Fanger M. W., Shen L., Pugh J., Bernier G. M. Subpopulations of human peripheral granulocyes and monocytes express receptors for IgA. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3640–3644. doi: 10.1073/pnas.77.6.3640. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Frandsen E. V., Theilade E., Ellegaard B., Kilian M. Proportions and identity of IgA1-degrading bacteria in periodontal pockets from patients with juvenile and rapidly progressive periodontitis. J Periodontal Res. 1986 Nov;21(6):613–623. doi: 10.1111/j.1600-0765.1986.tb01498.x. [DOI] [PubMed] [Google Scholar]
  13. Fujiyama Y., Kobayashi K., Senda S., Benno Y., Bamba T., Hosoda S. A novel IgA protease from Clostridium sp. capable of cleaving IgA1 and IgA2 A2m(1) but not IgA2 A2m(2) allotype paraproteins. J Immunol. 1985 Jan;134(1):573–576. [PubMed] [Google Scholar]
  14. Funakoshi S., Doi T., Nakajima T., Suyama T., Tokuda M. Antimicrobial effect of human serum IgA. Microbiol Immunol. 1982;26(3):227–239. doi: 10.1111/j.1348-0421.1982.tb00174.x. [DOI] [PubMed] [Google Scholar]
  15. Gilbert J. V., Plaut A. G., Longmaid B., Lamm M. E. Inhibition of microbial IgA proteases by human secretory IgA and serum. Mol Immunol. 1983 Sep;20(9):1039–1049. doi: 10.1016/0161-5890(83)90045-7. [DOI] [PubMed] [Google Scholar]
  16. Gleeson M., Cripps A. W., Clancy R. L., Husband A. J., Hensley M. J., Leeder S. R. Ontogeny of the secretory immune system in man. Aust N Z J Med. 1982 Aug;12(4):255–258. doi: 10.1111/j.1445-5994.1982.tb03806.x. [DOI] [PubMed] [Google Scholar]
  17. Gorter A., Hiemstra P. S., Leijh P. C., van der Sluys M. E., van den Barselaar M. T., van Es L. A., Daha M. R. IgA- and secretory IgA-opsonized S. aureus induce a respiratory burst and phagocytosis by polymorphonuclear leucocytes. Immunology. 1987 Jul;61(3):303–309. [PMC free article] [PubMed] [Google Scholar]
  18. Griffiss J. M. Biologic function of the serum IgA system: modulation of complement-mediated effector mechanisms and conservation of antigenic mass. Ann N Y Acad Sci. 1983 Jun 30;409:697–707. doi: 10.1111/j.1749-6632.1983.tb26909.x. [DOI] [PubMed] [Google Scholar]
  19. Heddle R. J., Knop J., Steele E. J., Rowley D. The effect of lysozyme on the complement-dependent bactericidal action of different antibody classes. Immunology. 1975 Jun;28(6):1061–1066. [PMC free article] [PubMed] [Google Scholar]
  20. Hiemstra P. S., Gorter A., Stuurman M. E., Van Es L. A., Daha M. R. Activation of the alternative pathway of complement by human serum IgA. Eur J Immunol. 1987 Mar;17(3):321–326. doi: 10.1002/eji.1830170304. [DOI] [PubMed] [Google Scholar]
  21. Holmgren J., Andersson A., Wallerstrom G., Ouchterlony O. Experimental studies on cholera immunization. II. Evidence for protective antitoxic immunity mediated by serum antibodies as well as local antibodies. Infect Immun. 1972 May;5(5):662–667. doi: 10.1128/iai.5.5.662-667.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Iida K., Fujita T., Inai S., Sasaki M., Kato T. Complement fixing abilities of IgA myeloma proteins and their fragments: the activation of complement through the classical pathway. Immunochemistry. 1976 Sep;13(9):747–752. doi: 10.1016/0019-2791(76)90195-6. [DOI] [PubMed] [Google Scholar]
  23. Kaplan B. S., Uni S., Aikawa M., Mahmoud A. A. Effector mechanism of host resistance in murine giardiasis: specific IgG and IgA cell-mediated toxicity. J Immunol. 1985 Mar;134(3):1975–1981. [PubMed] [Google Scholar]
  24. Kemp A. S., Cripps A. W., Brown S. Suppression of leucocyte chemokinesis and chemotaxis by human IgA. Clin Exp Immunol. 1980 May;40(2):388–395. [PMC free article] [PubMed] [Google Scholar]
  25. Kett K., Brandtzaeg P., Radl J., Haaijman J. J. Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues. J Immunol. 1986 May 15;136(10):3631–3635. [PubMed] [Google Scholar]
  26. Kilian M., Reinholdt J. A hypothetical model for the development of invasive infection due to IgA1 protease-producing bacteria. Adv Exp Med Biol. 1987;216B:1261–1269. [PubMed] [Google Scholar]
  27. Liljemark W. F., Bloomquist C. G., Ofstehage J. C. Aggregation and adherence of Streptococcus sanguis: role of human salivary immunoglobulin A. Infect Immun. 1979 Dec;26(3):1104–1110. doi: 10.1128/iai.26.3.1104-1110.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Lim P. L., Rowley D. The effect of antibody on the intestinal absorption of macromolecules and on intestinal permeability in adult mice. Int Arch Allergy Appl Immunol. 1982;68(1):41–46. doi: 10.1159/000233065. [DOI] [PubMed] [Google Scholar]
  29. Lowell G. H., Smith L. F., Griffiss J. M., Brandt B. L., MacDermott R. P. Antibody-dependent mononuclear cell-mediated antimeningococcal activity. Comparison of the effects of convalescent and postimmunization immunoglobulins G, M, and A. J Clin Invest. 1980 Aug;66(2):260–267. doi: 10.1172/JCI109852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Magnusson K. E., Stendahl O., Stjernström I., Edebo L. Reduction of phagocytosis, surface hydrophobicity and charge of Salmonella typhimurium 395 MR10 by reaction with secretory IgA (SIgA). Immunology. 1979 Mar;36(3):439–447. [PMC free article] [PubMed] [Google Scholar]
  31. Magnusson K. E., Stjernström I. Mucosal barrier mechanisms. Interplay between secretory IgA (SIgA), IgG and mucins on the surface properties and association of salmonellae with intestine and granulocytes. Immunology. 1982 Feb;45(2):239–248. [PMC free article] [PubMed] [Google Scholar]
  32. Mansa B., Kilian M. Retained antigen-binding activity of Fab alpha fragments of human monoclonal immunoglobulin A1 (IgA1) cleaved by IgA1 protease. Infect Immun. 1986 Apr;52(1):171–174. doi: 10.1128/iai.52.1.171-174.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Mathew G. D., Qualtiere L. F., Neel H. B., 3rd, Pearson G. R. IgA antibody, antibody-dependent cellular cytotoxicity and prognosis in patients with nasopharyngeal carcinoma. Int J Cancer. 1981 Feb 15;27(2):175–180. doi: 10.1002/ijc.2910270208. [DOI] [PubMed] [Google Scholar]
  34. McGhee J. R., Michalek S. M. Immunobiology of dental caries: microbial aspects and local immunity. Annu Rev Microbiol. 1981;35:595–638. doi: 10.1146/annurev.mi.35.100181.003115. [DOI] [PubMed] [Google Scholar]
  35. Mehta S. K., Plaut A. G., Calvanico N. J., Tomasi T. B., Jr Human immunoglobulin A: production of an Fc fragment by an enteric microbial proteolytic enzyme. J Immunol. 1973 Oct;111(4):1274–1276. [PubMed] [Google Scholar]
  36. Mestecky J., Kilian M. Immunoglobulin A (IgA). Methods Enzymol. 1985;116:37–75. doi: 10.1016/s0076-6879(85)16005-2. [DOI] [PubMed] [Google Scholar]
  37. Mestecky J., McGhee J. R. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol. 1987;40:153–245. doi: 10.1016/s0065-2776(08)60240-0. [DOI] [PubMed] [Google Scholar]
  38. Mestecky J., Russell M. W. IgA subclasses. Monogr Allergy. 1986;19:277–301. [PubMed] [Google Scholar]
  39. Milazzo F. H., Delisle G. J. Immunoglobulin A proteases in gram-negative bacteria isolated from human urinary tract infections. Infect Immun. 1984 Jan;43(1):11–13. doi: 10.1128/iai.43.1.11-13.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Mostov K. E., Friedlander M., Blobel G. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature. 1984 Mar 1;308(5954):37–43. doi: 10.1038/308037a0. [DOI] [PubMed] [Google Scholar]
  41. Musher D. M., Goree A., Baughn R. E., Birdsall H. H. Immunoglobulin A from bronchopulmonary secretions blocks bactericidal and opsonizing effects of antibody to nontypable Haemophilus influenzae. Infect Immun. 1984 Jul;45(1):36–40. doi: 10.1128/iai.45.1.36-40.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Méndez E., Fernández-Luna J. L., Grubb A., Leyva-Cobián F. Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1472–1475. doi: 10.1073/pnas.83.5.1472. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Nguyen T. D., Bottreau E., Bernard S., Lantier I., Aynaud J. M. Neutralizing secretory IgA and IgG do not inhibit attachment of transmissible gastroenteritis virus. J Gen Virol. 1986 May;67(Pt 5):939–943. doi: 10.1099/0022-1317-67-5-939. [DOI] [PubMed] [Google Scholar]
  44. O'Neill P. A., Romsdahl M. M. IgA as a blocking factor in human malignant melanoma. Immunol Commun. 1974;3(5):427–438. doi: 10.3109/08820137409061123. [DOI] [PubMed] [Google Scholar]
  45. Peppard J., Orlans E., Payne A. W., Andrew E. The elimination of circulating complexes containing polymeric IgA by excretion in the bile. Immunology. 1981 Jan;42(1):83–89. [PMC free article] [PubMed] [Google Scholar]
  46. Pfaffenbach G., Lamm M. E., Gigli I. Activation of the guinea pig alternative complement pathway by mouse IgA immune complexes. J Exp Med. 1982 Jan 1;155(1):231–247. doi: 10.1084/jem.155.1.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Plaut A. G. The IgA1 proteases of pathogenic bacteria. Annu Rev Microbiol. 1983;37:603–622. doi: 10.1146/annurev.mi.37.100183.003131. [DOI] [PubMed] [Google Scholar]
  48. Reinholdt J., Kilian M. Interference of IgA protease with the effect of secretory IgA on adherence of oral streptococci to saliva-coated hydroxyapatite. J Dent Res. 1987 Feb;66(2):492–497. doi: 10.1177/00220345870660021801. [DOI] [PubMed] [Google Scholar]
  49. Richards C. D., Gauldie J. IgA-mediated phagocytosis by mouse alveolar macrophages. Am Rev Respir Dis. 1985 Jul;132(1):82–85. doi: 10.1164/arrd.1985.132.1.82. [DOI] [PubMed] [Google Scholar]
  50. Rits M., Kints J. P., Bazin H., Vaerman J. P. Rat C3 conversion by rat anti-2,4,dinitrophenyl (DNP) hapten IgA immune precipitates. Scand J Immunol. 1987 Apr;25(4):359–366. doi: 10.1111/j.1365-3083.1987.tb02201.x. [DOI] [PubMed] [Google Scholar]
  51. Russell-Jones G. J., Ey P. L., Reynolds B. L. Inhibition of cutaneous anaphylaxis and arthus reactions in the mouse by antigen-specific IgA. Int Arch Allergy Appl Immunol. 1981;66(3):316–325. doi: 10.1159/000232836. [DOI] [PubMed] [Google Scholar]
  52. Russell-Jones G. J., Ey P. L., Reynolds B. L. The ability of IgA to inhibit the complement-mediated lysis of target red blood cells sensitized with IgG antibody. Mol Immunol. 1980 Sep;17(9):1173–1180. doi: 10.1016/0161-5890(80)90114-5. [DOI] [PubMed] [Google Scholar]
  53. Russell M. W., Brown T. A., Claflin J. L., Schroer K., Mestecky J. Immunoglobulin A-mediated hepatobiliary transport constitutes a natural pathway for disposing of bacterial antigens. Infect Immun. 1983 Dec;42(3):1041–1048. doi: 10.1128/iai.42.3.1041-1048.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Shedlofsky S., Freter R. Synergism between ecologic and immunologic control mechanisms of intestinal flora. J Infect Dis. 1974 Mar;129(3):296–303. doi: 10.1093/infdis/129.3.296. [DOI] [PubMed] [Google Scholar]
  55. Sibille Y., Delacroix D. L., Merill W. W., Chatelain B., Vaerman J. P. IgA-induced chemokinesis of human polymorphonuclear neutrophils: requirement of their Fc-alpha receptor. Mol Immunol. 1987 Jun;24(6):551–559. doi: 10.1016/0161-5890(87)90035-6. [DOI] [PubMed] [Google Scholar]
  56. Smith D. J., Taubman M. A., Ebersole J. L. Effects of local immunization with glucosyltransferase on colonization of hamsters by Streptococcus mutans. Infect Immun. 1982 Aug;37(2):656–661. doi: 10.1128/iai.37.2.656-661.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Stokes C. R., Soothill J. F., Turner M. W. Immune exclusion is a function of IgA. Nature. 1975 Jun 26;255(5511):745–746. doi: 10.1038/255745a0. [DOI] [PubMed] [Google Scholar]
  58. Svanborg Edén C., Andersson B., Hagberg L., Hanson L. A., Leffler H., Magnusson G., Noori G., Dahmén J., Söderström T. Receptor analogues and anti-pili antibodies as inhibitors of bacterial attachment in vivo and in vitro. Ann N Y Acad Sci. 1983 Jun 30;409:580–592. doi: 10.1111/j.1749-6632.1983.tb26900.x. [DOI] [PubMed] [Google Scholar]
  59. Sørensen C. H., Kilian M. Bacterium-induced cleavage of IgA in nasopharyngeal secretions from atopic children. Acta Pathol Microbiol Immunol Scand C. 1984 Feb;92(1):85–87. doi: 10.1111/j.1699-0463.1984.tb00056.x. [DOI] [PubMed] [Google Scholar]
  60. Tagliabue A., Boraschi D., Villa L., Keren D. F., Lowell G. H., Rappuoli R., Nencioni L. IgA-dependent cell-mediated activity against enteropathogenic bacteria: distribution, specificity, and characterization of the effector cells. J Immunol. 1984 Aug;133(2):988–992. [PubMed] [Google Scholar]
  61. Tagliabue A., Villa L., Boraschi D., Peri G., de Gori V., Nencioni L. Natural anti-bacterial activity against Salmonella typhi by human T4+ lymphocytes armed with IgA antibodies. J Immunol. 1985 Dec;135(6):4178–4182. [PubMed] [Google Scholar]
  62. Taylor H. P., Dimmock N. J. Mechanism of neutralization of influenza virus by secretory IgA is different from that of monomeric IgA or IgG. J Exp Med. 1985 Jan 1;161(1):198–209. doi: 10.1084/jem.161.1.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Tenovuo J., Moldoveanu Z., Mestecky J., Pruitt K. M., Rahemtulla B. M. Interaction of specific and innate factors of immunity: IgA enhances the antimicrobial effect of the lactoperoxidase system against Streptococcus mutans. J Immunol. 1982 Feb;128(2):726–731. [PubMed] [Google Scholar]
  64. Tolo K., Brandtzaeg P., Jonsen J. Mucosal penetration of antigen in the presence or absence of serum-derived antibody. Immunology. 1977 Nov;33(5):733–743. [PMC free article] [PubMed] [Google Scholar]
  65. Tramont E. C., Ciak J., Boslego J., McChesney D. G., Brinton C. C., Zollinger W. Antigenic specificity of antibodies in vaginal secretions during infection with Neisseria gonorrhoeae. J Infect Dis. 1980 Jul;142(1):23–31. doi: 10.1093/infdis/142.1.23. [DOI] [PubMed] [Google Scholar]
  66. Underdown B. J., Schiff J. M. Immunoglobulin A: strategic defense initiative at the mucosal surface. Annu Rev Immunol. 1986;4:389–417. doi: 10.1146/annurev.iy.04.040186.002133. [DOI] [PubMed] [Google Scholar]
  67. Van Epps D. E., Plaut A., Bernier G. M., Williams R. C., Jr IgA paraprotein inhibition of human neutrophil chemotaxis. Reduced activity following treatment with IgA-specific protease from Neisseria gonorrhoeae. Inflammation. 1980 Jun;4(2):137–144. doi: 10.1007/BF00914160. [DOI] [PubMed] [Google Scholar]
  68. Van Epps D. E., Reed K., Williams R. C., Jr Suppression of human PMN bactericidal activity by human IgA paraproteins. Cell Immunol. 1978 Mar 15;36(2):363–376. doi: 10.1016/0008-8749(78)90280-0. [DOI] [PubMed] [Google Scholar]
  69. Walker W. A., Isselbacher K. J., Bloch K. J. Intestinal uptake of macromolecules: effect of oral immunization. Science. 1972 Aug 18;177(4049):608–610. doi: 10.1126/science.177.4049.608. [DOI] [PubMed] [Google Scholar]
  70. Watanabe T., Nagura H., Watanabe K., Brown W. R. The binding of human milk lactoferrin to immunoglobulin A. FEBS Lett. 1984 Mar 26;168(2):203–207. doi: 10.1016/0014-5793(84)80246-x. [DOI] [PubMed] [Google Scholar]
  71. Wilson I. D. Studies on the opsonic activity of human secretory IgA using an in vitro phagocytosis system. J Immunol. 1972 Mar;108(3):726–730. [PubMed] [Google Scholar]
  72. Wilton J. M. Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leucocytes. Clin Exp Immunol. 1978 Dec;34(3):423–428. [PMC free article] [PubMed] [Google Scholar]
  73. Zipursky A., Brown E. J., Bienenstock J. Lack of opsonization potential of 11S human secretory A. Proc Soc Exp Biol Med. 1973 Jan;142(1):181–184. doi: 10.3181/00379727-142-36983. [DOI] [PubMed] [Google Scholar]

Articles from Microbiological Reviews are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES