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. Author manuscript; available in PMC: 2014 Aug 12.
Published in final edited form as: Vaccine. 2013 Jun 15;31(36):3675–3682. doi: 10.1016/j.vaccine.2013.06.010

Figure 5. Basophil depletion attenuates cellular responses induced by irradiated L3 vaccine.

Figure 5

A) Timeline of experimental protocol. Both vaccinated (Vacc) and vaccinated and basophil-depleted (Vacc+Depl) groups were vaccinated with three weekly subcutaneous injections of 25 irradiated L3s. A control group of mice was not vaccinated (No Vacc). From days -2 (2 days prior to vaccination) to day 28 mice were administered weekly injections of Ba103 to deplete basophils (Vacc+Depl) or isotype control antibody (No Vacc and Vacc groups). No mice were challenged with infective L3 larvae in this study. B) Proliferation and C–F) cytokine production of splenic CD4+ T-cells in response to parasite antigen measured after 3 days of culture. (PI = proliferative index; * p < 0.5; ** p < 0.01; *** p < 0.001; NS not significant).