Table 1.

Cohort Characteristics

Characteristics	Total	p16+ve	p16−ve	p-value	HPV16+ve	HPV16−ve	p-value
	N=80	N=21 (%)	N=59 (%)		N=40 (%)	N=40 (%)
Gender
Male	66	16 (24)	50 (76)	0.376	34	32	0.556
Female	14	5 (36)	9 (64)		6	8
Age Group
≤50 years	12	5 (42)	7 (58)	0.302	8 (67)	4 (33)	0.293
51-65 years	32	9 (28)	23 (72)		17 (53)	15 (47)
>65 years	36	7(19)	29 (81)		15 (42)	21 (58)
Marital Status ∞
Unmarried	28	12 (43)	16 (57)	0.008†	12 (43)	16 (57)	0.254
Married	46	7 (15)	39 (85)		26 (57)	20 (43)
Smoking
Never smoker	10	6 (60)	4 (40)	0.014†	7 (70)	3 (30)	0.455
Past smoker	27	9 (33)	18 (67)		12 (44)	15 (56)
Current smoker	39	6 (15)	33 (85)		20 (51)	19 (49)
Race *
Caucasian American (CA)	40	15 (38)	25 (62)	0.031†	26 (65)	14 (35)	0.013†
African American (AA)	38	6 (16)	32 (84)		14 (37)	24 (63)
p16 Status
Positive	21				12 (57)	9 (43)	0.446
Negative	59				28 (47)	31(53)
HPV16 Status
Positive	40	12 (30)	28 (70)	0.446
Negative	40	9 (23)	31 (77)
Sites
Oropharynx	20	13 (65)	7 (35)	<0.001†	10 (50)	10 (50)	1.000
Non-Oropharynx	60	8 (13)	52 (87)		30 (50)	30 (50)
Oral Cavity	20	4 (20)	16 (80)	0.004†	10 (50)	10 (50)
Larynx	20	3 (15)	17 (85)	0.001†	10 (50)	10 (50)
Hypopharynx	20	1 (5)	19 (95)	<0.001†	10 (50)	10 (50)
Stage
Early	19	2 (11)	17 (89)	0.073	8 (42)	11 (58)	0.792
Late	53	18 (34)	35 (66)		25 (47)	28 (53)

^∞Marital status missing for 6 cases;

^*Other race (N=2) are p16 negative, HPV16 negative and are located in Hypopharynx;

^†significant p-values; OP - oropharynx; p16+ve: p16 positive, p16−ve: p16 negative, HPV16+ve: HPV16 positive, HPV16−ve: HPV16 negative