Days |
Experiment |
Preday -30 |
Rats were purchased from Harlen Industries |
Preday -27 |
Initial filament testing was performed |
Preday -26 |
Cannulation of the trigeminal ganglia was completed |
Preday -20 |
Cannulated rats were placed in the feeder units |
Preday -14 |
Filament testing was performed |
Preday -7 |
Filament testing was performed |
Preday -3 |
Feeding data and body weight was analyzed |
Preday -2 |
Feeding data and body weight was analyzed |
Preday -1 |
Feeding data and body weight was analyzed |
Lig +1 |
Ligature placed on the tendon on the morning of day ligature 1 and feeding data and body weight was analyzed |
Lig +2 |
Feeding data and body weight was analyzed |
Lig +3 |
Feeding data and body weight was analyzed and filament testing was performed |
Lig +4/siRNA +1 |
siRNA infused into the trigeminal ganglia on the morning of day siRNA 1 and feeding data and body weight was analyzed |
Lig +5/siRNA +2 |
Feeding data and body weight was analyzed |
Lig +6/siRNA +3 |
Feeding data and body weight was analyzed and filament testing was performed |
Sacrifice |
72 h after siRNA infusion the animals were sacrificed and the trigeminal ganglia and trigeminal nucleus caudalis tissue was isolated |