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. 2013 Jul 20;3(8):544–560. doi: 10.7150/thno.5634

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 5 — (A) Schematic illustration of the 124I-cRGDY-PEG-ylated core-shellsilica NP with surface-bearing radiolabels and peptides and core-containing reactive dye molecules (insets).(B) Representative whole-body coronal micro PET images at 24-hours demonstrating M21 (left, arrow)) tumor uptakes of 3.6 %ID/g. %ID/g indicates the percentage of the injected dose (ID)of PEG-silica NP per gram tissue.and(C) enhanced M21 tumor contrast at 24 hours (right). (D) Whole-body fluorescence image of the tumor site 10 minutes after subdermal PEG-silica nanoparticle injection. (E) Delayed whole-body fluorescence image of the tumor site 1 hour after PEG-silica NPinjection. (Reprinted and Adapted with permission from ASCI, reference 69).