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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Leukemia. 2010 Jun 24;24(9):1555–1565. doi: 10.1038/leu.2010.142

Figure 5. Caspase activation in IM-9 cells treated with HXR9 alone and in combination with ch128.1Av.

Figure 5

A) Caspase activity in IM-9 cells treated with 40 µM HXR9 or 20 µM HXR9 alone at various time points. At each time point cells were lysed and caspase activation was determined using flourogenic caspase substrates: Ac-IETD-AMC (caspase-8), Ac-LEHD-AMC (capase-9), Ac-DMQD-AMC (caspase-3), or Ac-VDVAD-AMC (caspase-2). B) Cells treated with 2.5 nM ch128.1Av, 20 µM HXR9, or the two in combination at the times indicated. Fold activation is expressed as the ratio of treated cells over buffer alone treated cells. Data are representative of three independent experiments.